Structural insights into SARS-CoV-2 proteins
The unprecedented scale of the ongoing COVID-19 pandemic has catalyzed an intense
effort of the global scientific community to unravel different aspects of the disease in a short …
effort of the global scientific community to unravel different aspects of the disease in a short …
Structure and function of major SARS-CoV-2 and SARS-CoV proteins
SARS-CoV-2 virus, the causative agent of COVID-19 pandemic, has a genomic organization
consisting of 16 nonstructural proteins (nsps), 4 structural proteins, and 9 accessory …
consisting of 16 nonstructural proteins (nsps), 4 structural proteins, and 9 accessory …
Crystal structure of Nsp15 endoribonuclease NendoU from SARS‐CoV‐2
Y Kim, R Jedrzejczak, NI Maltseva… - Protein …, 2020 - Wiley Online Library
Abstract Severe Acute Respiratory Syndrome coronavirus 2 (SARS‐CoV‐2) is rapidly
spreading around the world. There is no existing vaccine or proven drug to prevent …
spreading around the world. There is no existing vaccine or proven drug to prevent …
Coronavirus endoribonuclease targets viral polyuridine sequences to evade activating host sensors
Coronaviruses (CoVs) are positive-sense RNA viruses that can emerge from endemic
reservoirs and infect zoonotically, causing significant morbidity and mortality. CoVs encode …
reservoirs and infect zoonotically, causing significant morbidity and mortality. CoVs encode …
The nonstructural proteins directing coronavirus RNA synthesis and processing
Coronaviruses are animal and human pathogens that can cause lethal zoonotic infections
like SARS and MERS. They have polycistronic plus-stranded RNA genomes and belong to …
like SARS and MERS. They have polycistronic plus-stranded RNA genomes and belong to …
Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages
X Deng, M Hackbart, RC Mettelman… - Proceedings of the …, 2017 - National Acad Sciences
Coronaviruses are positive-sense RNA viruses that generate double-stranded RNA
(dsRNA) intermediates during replication, yet evade detection by host innate immune …
(dsRNA) intermediates during replication, yet evade detection by host innate immune …
One year of SARS-CoV-2: how much has the virus changed?
S Vilar, DG Isom - Biology, 2021 - mdpi.com
Simple Summary Now that vaccines have been developed and are being deployed to
address the COVID-19 pandemic, a major concern is the emergence of mutations in severe …
address the COVID-19 pandemic, a major concern is the emergence of mutations in severe …
Coronavirus pathogenesis
SR Weiss, JL Leibowitz - Advances in virus research, 2011 - Elsevier
Coronaviruses infect many species of animals including humans, causing acute and chronic
diseases. This review focuses primarily on the pathogenesis of murine coronavirus mouse …
diseases. This review focuses primarily on the pathogenesis of murine coronavirus mouse …
Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2
Abstract SARS-CoV-2 Nsp15 is a uridine-specific endoribonuclease with C-terminal catalytic
domain belonging to the EndoU family that is highly conserved in coronaviruses. As …
domain belonging to the EndoU family that is highly conserved in coronaviruses. As …
Potential drug targets of SARS-CoV-2: From genomics to therapeutics
The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) from
China has become a global threat due to the continuous rise in cases of Coronavirus …
China has become a global threat due to the continuous rise in cases of Coronavirus …