One of the most important causes of neurological morbidity and mortality in the world is
ischemic stroke. It can be a result of multiple events such as embolism with a cardiac origin …

Inflammation plays an important role in the pathogenesis of ischemic stroke and other forms
of ischemic brain injury. Increasing evidence suggests that inflammatory response is a …

This review covers the pathogenesis of ischemic stroke and future directions regarding
therapeutic options after injury. Ischemic stroke is a devastating disease process affecting …

Cytokines have been implicated as mediators and inhibitors of diverse forms of
neurodegeneration. They are induced in response to brain injury and have diverse actions …

Inflammation is a hallmark of stroke pathology. The cytokines, tumor necrosis factor (TNF),
interleukin (IL)-1, and IL-6, modulate tissue injury in experimental stroke and are therefore …

Rodent stroke models provide the experimental backbone for the in vivo determination of the
mechanisms of cell death and neural repair, and for the initial testing of neuroprotective …

Activation of microglia and expression of the inflammatory cytokine interleukin-1 (IL-1) in the
CNS have become almost synonymous with neuroinflammation. In numerous studies …

BACKGROUND: A growing number of recent investigations have established a critical role
for leukocytes in propagating tissue damage after ischemia and reperfusion in stroke …

Background and Purpose Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine that
rapidly upregulates in the brain after injury. The present study was designed to explore the …

Contrary to previous dogmas, it is now well established that brain cells can produce
cytokines and chemokines, and can express adhesion molecules that enable an in situ …