Abstract The 1, 2, 3-triazole ring is a major pharmacophore system among nitrogen-
containing heterocycles. These five-membered heterocyclic motifs with three nitrogen …

The P2X7 receptor is a cation channel activated by high concentrations of adenosine
triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming …

Microglial activation is a distinguished attribute in many neurodegenerative diseases of
aging. Compelling evidence suggests that neuroinflammation stimulated by microglia, the …

JNJ-54175446 is a selective purine P2X7 receptor (P2X7R) antagonist that attenuates
microglial IL-1β/IL-18 release. In healthy volunteers, JNJ-54175446 suppressed peripheral …

An analysis of 66 published clinical candidates from Journal of Medicinal Chemistry has
been conducted to shed light on which lead generation strategies are most frequently …

The science of neuroimmunopsychiatry has evolved rapidly in the last few years with the
hope of tackling the unmet need in mood disorders. This article focuses on an inflammatory …

Neurodegenerative diseases (NDDs) represent a huge social burden, particularly in
Alzheimer's disease (AD) in which all proposed treatments investigated in murine models …

The ATP-gated P2X7 ion channel is an abundant microglial protein in the CNS that plays an
important pathological role in executing ATP-driven danger signal transduction. Emerging …

Alzheimer's disease (AD) is a major cause of age-related dementia, which is becoming a
global health crisis. However, the pathogenesis and etiology of AD are still not fully …

Abstract The P2X receptor 7 (P2X7R) is a plasma membrane receptor sensing extracellular
ATP associated with a wide variety of cellular functions. It is most commonly expressed on …