[HTML][HTML] Auditory neuropathy—neural and synaptic mechanisms
Sensorineural hearing impairment is the most common form of hearing loss, and
encompasses pathologies of the cochlea and the auditory nerve. Hearing impairment …
encompasses pathologies of the cochlea and the auditory nerve. Hearing impairment …
Zebrafish neurotransmitter systems as potential pharmacological and toxicological targets
EP Rico, DB Rosemberg, KJ Seibt, KM Capiotti… - Neurotoxicology and …, 2011 - Elsevier
Recent advances in neurobiology have emphasized the study of brain structure and function
and its association with numerous pathological and toxicological events. Neurotransmitters …
and its association with numerous pathological and toxicological events. Neurotransmitters …
[HTML][HTML] RNA granules hitchhike on lysosomes for long-distance transport, using annexin A11 as a molecular tether
Long-distance RNA transport enables local protein synthesis at metabolically-active sites
distant from the nucleus. This process ensures an appropriate spatial organization of …
distant from the nucleus. This process ensures an appropriate spatial organization of …
Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair
TO Auer, K Duroure, A De Cian, JP Concordet… - Genome …, 2014 - genome.cshlp.org
Sequence-specific nucleases like TALENs and the CRISPR/Cas9 system have greatly
expanded the genome editing possibilities in model organisms such as zebrafish. Both …
expanded the genome editing possibilities in model organisms such as zebrafish. Both …
[HTML][HTML] Conserved function of lincRNAs in vertebrate embryonic development despite rapid sequence evolution
Thousands of long intervening noncoding RNAs (lincRNAs) have been identified in
mammals. To better understand the evolution and functions of these enigmatic RNAs, we …
mammals. To better understand the evolution and functions of these enigmatic RNAs, we …
Restoration of hearing in the VGLUT3 knockout mouse using virally mediated gene therapy
Mice lacking the vesicular glutamate transporter-3 (VGLUT3) are congenitally deaf due to
loss of glutamate release at the inner hair cell afferent synapse. Cochlear delivery of …
loss of glutamate release at the inner hair cell afferent synapse. Cochlear delivery of …
Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature …
Reprogramming of the cochlea with hair-cell-specific transcription factors such as ATOH1
has been proposed as a potential therapeutic strategy for hearing loss. ATOH1 expression …
has been proposed as a potential therapeutic strategy for hearing loss. ATOH1 expression …
Decoding pancreatic endocrine cell differentiation and β cell regeneration in zebrafish
J Mi, KC Liu, O Andersson - Science Advances, 2023 - science.org
In contrast to mice, zebrafish have an exceptional yet elusive ability to replenish lost β cells
in adulthood. Understanding this framework would provide mechanistic insights for β cell …
in adulthood. Understanding this framework would provide mechanistic insights for β cell …
Different levels of Notch signaling regulate quiescence, renewal and differentiation in pancreatic endocrine progenitors
N Ninov, M Borius, DYR Stainier - Development, 2012 - journals.biologists.com
Genetic studies have implicated Notch signaling in the maintenance of pancreatic
progenitors. However, how Notch signaling regulates the quiescent, proliferative or …
progenitors. However, how Notch signaling regulates the quiescent, proliferative or …
Impairment of SLC17A8 encoding vesicular glutamate transporter-3, VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell dysfunction in null mice
Autosomal-dominant sensorineural hearing loss is genetically heterogeneous, with a
phenotype closely resembling presbycusis, the most common sensory defect associated …
phenotype closely resembling presbycusis, the most common sensory defect associated …