A review of computational drug repositioning: strategies, approaches, opportunities, challenges, and directions
Drug repositioning is the process of identifying novel therapeutic potentials for existing drugs
and discovering therapies for untreated diseases. Drug repositioning, therefore, plays an …
and discovering therapies for untreated diseases. Drug repositioning, therefore, plays an …
Leveraging big data analytics in healthcare enhancement: trends, challenges and opportunities
Clinical decisions are more promising and evidence-based, hence, big data analytics to
assist clinical decision-making has been expressed for a variety of clinical fields. Due to the …
assist clinical decision-making has been expressed for a variety of clinical fields. Due to the …
RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental …
Abstract The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB
PDB), the US data center for the global PDB archive and a founding member of the …
PDB), the US data center for the global PDB archive and a founding member of the …
RCSB Protein Data Bank: biological macromolecular structures enabling research and education in fundamental biology, biomedicine, biotechnology and energy
Abstract The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB
PDB, rcsb. org), the US data center for the global PDB archive, serves thousands of Data …
PDB, rcsb. org), the US data center for the global PDB archive, serves thousands of Data …
DrugBank 3.0: a comprehensive resource for 'omics' research on drugs
C Knox, V Law, T Jewison, P Liu, S Ly… - Nucleic acids …, 2010 - academic.oup.com
Abstract DrugBank (http://www. drugbank. ca) is a richly annotated database of drug and
drug target information. It contains extensive data on the nomenclature, ontology, chemistry …
drug target information. It contains extensive data on the nomenclature, ontology, chemistry …
Statistical potential for assessment and prediction of protein structures
Protein structures in the Protein Data Bank provide a wealth of data about the interactions
that determine the native states of proteins. Using the probability theory, we derive an atomic …
that determine the native states of proteins. Using the probability theory, we derive an atomic …
UniRef: comprehensive and non-redundant UniProt reference clusters
BE Suzek, H Huang, P McGarvey, R Mazumder… - …, 2007 - academic.oup.com
Motivation: Redundant protein sequences in biological databases hinder sequence
similarity searches and make interpretation of search results difficult. Clustering of protein …
similarity searches and make interpretation of search results difficult. Clustering of protein …
Database resources of the national center for biotechnology information
DL Wheeler, T Barrett, DA Benson… - Nucleic acids …, 2007 - academic.oup.com
In addition to maintaining the GenBank (R) nucleic acid sequence database, the National
Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for …
Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for …
Prediction of protein solubility based on sequence physicochemical patterns and distributed representation information with DeepSoluE
Background Protein solubility is a precondition for efficient heterologous protein expression
at the basis of most industrial applications and for functional interpretation in basic research …
at the basis of most industrial applications and for functional interpretation in basic research …
The worldwide Protein Data Bank (wwPDB): ensuring a single, uniform archive of PDB data
Abstract The worldwide Protein Data Bank (wwPDB) is the international collaboration that
manages the deposition, processing and distribution of the PDB archive. The online PDB …
manages the deposition, processing and distribution of the PDB archive. The online PDB …