Increasing evidence suggests that mechanics play a critical role in regulating brain function
at different scales. Downstream integration of mechanical inputs into biochemical signals …

The mechanical properties of the nucleus influence different cellular and nuclear functions
and have relevant implications for several human diseases. The nucleus protects genetic …

Nuclear Ca2+ waves elicited by NMDAR and L-type voltage-gated Ca2+-channels as well
as protein transport from synapse-to-nucleus are both instrumental in control of plasticity …

Cell morphology, architecture and dynamics primarily rely on intracellular cytoskeletal
networks, which in metazoans are mainly composed of actin microfilaments, microtubules …

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by a CAG
repeat expansion in the huntingtin gene (HTT). Disease progression is characterized by the …

The role of lamin B1 in human health and aging has attracted increasing attention as
mounting evidence reveals its significance in diverse cellular processes. Both upregulation …

The organization of eukaryotic genome in the nucleus, a double-membraned organelle
separated from the cytoplasm, is highly complex and dynamic. The functional architecture of …

Peripheral heterochromatin positioning depends on nuclear envelope associated proteins
and repressive histone modifications. Here we show that overexpression (OE) of Lamin B1 …

Huntington's disease (HD) is a complex neurodegenerative disorder with considerable
heterogeneity in clinical manifestations. While CAG repeat length is a known predictor of …

Neurons decline in their functionality over time, and age‐related neuronal alterations are
associated with phenotypes of neurodegenerative diseases. In nonneural tissues, an …