Stroke and late-onset Alzheimer's disease (AD) are risk factors for each other; the
comorbidity of these brain disorders in aging individuals represents a significant challenge …

This comprehensive review discusses clinical studies of patients following brain injuries
(traumatic, acquired, or stroke), who have been treated with amantadine or memantine. Both …

Cortical spreading depolarization (CSD) is a promising target for neuroprotective therapy in
traumatic brain injury (TBI). We explored the effect of NMDA receptor antagonism on …

Memantine and ketamine are clinically useful NMDA receptor (NMDAR) open channel
blockers that inhibit NMDARs with similar potency and kinetics, but display vastly different …

Intracerebral hemorrhage (ICH) may be caused by trauma, aneurysm and arteriovenous
malformation, as can any bleeding within the intracranial vault, including brain parenchyma …

Ischemic stroke, the second leading cause of death worldwide, leads to excessive glutamate
release, over-activation of N-methyl-D-aspartate receptor (NMDAR), and massive influx of …

Cardiac arrest has many implications for morbidity and mortality. Few interventions have
been shown to improve return of spontaneous circulation (ROSC) and long‐term outcomes …

Deficiencies in N‐methyl‐d‐aspartate (NMDA)/glutamate receptor (NMDAR) signaling have
been considered central to the cognitive impairments of schizophrenia; however, an …

Traumatic brain injury (TBI) is a major cause of disability and death globally. Despite
significant progress in neuromonitoring and neuroprotection, pharmacological interventions …

Повышение эффективности реабилитации больных после инсульта остается одной из
важнейших стратегических задач российского здравоохранения. Когнитивные …