In 1969, Dr. Oscar Ratnoff, a pioneer in delineating the mechanisms by which coagulation is
activated and complement is regulated, wrote,“In the study of biological processes, the …

A fine-tuned activation and deactivation of proteases and their inhibitors are involved in the
execution of the inflammatory response. The zymogen/proenzyme plasminogen is converted …

Nrf2 is a transcription factor that regulates cellular redox balance and the expression of a
wide array of genes involved in immunity and inflammation, including antiviral actions. Nrf2 …

Aims The molecular pathogenesis of COVID-19 is similar to other coronavirus (CoV)
infections viz. severe acute respiratory syndrome (SARS) in human. Due to scarcity of the …

Fibrotic diseases, such as systemic sclerosis (SSc), idiopathic pulmonary fibrosis, renal
fibrosis and liver cirrhosis are characterized by tissue overgrowth due to excessive …

The COVID-19 pandemic has once again brought to the forefront the existence of a tight link
between the coagulation/fibrinolytic system and the immunologic processes. Tissue-type …

The oral cavity is a unique environment that consists of teeth surrounded by periodontal
tissues, oral mucosae with minor salivary glands, and terminal parts of major salivary glands …

Two of the most predominant features of the Alzheimer's disease (AD) brain are deposition
of β-amyloid (Aβ) plaques and inflammation. The mechanism behind these pathologies …

HLH is a rare condition that can be responsible of life-threatening organ failure. The
pathophysiology relies on a defect of cytotoxicity resulting in an uncontrolled inflammatory …

MMP-9 plays a number of important physiological functions but is also responsible for many
pathological processes, including cancer invasion, metastasis, and angiogenesis. It is …