[HTML][HTML] Pseudomonas aeruginosa evolutionary adaptation and diversification in cystic fibrosis chronic lung infections
Pseudomonas aeruginosa populations undergo a characteristic evolutionary adaptation
during chronic infection of the cystic fibrosis (CF) lung, including reduced production of …
during chronic infection of the cystic fibrosis (CF) lung, including reduced production of …
Epidemiology, biology, and impact of clonal Pseudomonas aeruginosa infections in cystic fibrosis
MD Parkins, R Somayaji, VJ Waters - Clinical microbiology …, 2018 - Am Soc Microbiol
Chronic lower airway infection with Pseudomonas aeruginosa is a major contributor to
morbidity and mortality in individuals suffering from the genetic disease cystic fibrosis (CF) …
morbidity and mortality in individuals suffering from the genetic disease cystic fibrosis (CF) …
Application of a quantitative framework to improve the accuracy of a bacterial infection model
GR Lewin, A Kapur, DM Cornforth… - Proceedings of the …, 2023 - National Acad Sciences
Laboratory models are critical to basic and translational microbiology research. Models
serve multiple purposes, from providing tractable systems to study cell biology to allowing …
serve multiple purposes, from providing tractable systems to study cell biology to allowing …
[PDF][PDF] Drug-driven phenotypic convergence supports rational treatment strategies of chronic infections
Chronic Pseudomonas aeruginosa infections evade antibiotic therapy and are associated
with mortality in cystic fibrosis (CF) patients. We find that in vitro resistance evolution of P …
with mortality in cystic fibrosis (CF) patients. We find that in vitro resistance evolution of P …
[HTML][HTML] How bacterial adaptation to cystic fibrosis environment shapes interactions between Pseudomonas aeruginosa and Staphylococcus aureus
L Camus, P Briaud, F Vandenesch… - Frontiers in …, 2021 - frontiersin.org
Pseudomonas aeruginosa and Staphylococcus aureus are the two most prevalent bacteria
species in the lungs of cystic fibrosis (CF) patients and are associated with poor clinical …
species in the lungs of cystic fibrosis (CF) patients and are associated with poor clinical …
[HTML][HTML] From genotype to phenotype: adaptations of Pseudomonas aeruginosa to the cystic fibrosis environment
L Camus, F Vandenesch, K Moreau - Microbial genomics, 2021 - microbiologyresearch.org
Pseudomonas aeruginosa is one of the main microbial species colonizing the lungs of cystic
fibrosis patients and is responsible for the decline in respiratory function. Despite the hostile …
fibrosis patients and is responsible for the decline in respiratory function. Despite the hostile …
Within-host evolution of bacterial pathogens during persistent infection of humans
Highlights•Some persistent infections are linked to drug resistance and adverse outcomes
such as cancer.•Longitudinal human-infection studies offer access to early and late infection …
such as cancer.•Longitudinal human-infection studies offer access to early and late infection …
[HTML][HTML] The evolutionary trajectories of P. aeruginosa in biofilm and planktonic growth modes exposed to ciprofloxacin: beyond selection of antibiotic resistance
MN Ahmed, A Abdelsamad, T Wassermann… - NPJ biofilms and …, 2020 - nature.com
Ciprofloxacin (CIP) is used to treat Pseudomonas aeruginosa biofilm infections. We showed
that the pathways of CIP-resistance development during exposure of biofilms and planktonic …
that the pathways of CIP-resistance development during exposure of biofilms and planktonic …
Common adaptive strategies underlie within-host evolution of bacterial pathogens
YE Gatt, H Margalit - Molecular biology and evolution, 2021 - academic.oup.com
Within-host adaptation is a hallmark of chronic bacterial infections, involving substantial
genomic changes. Recent large-scale genomic data from prolonged infections allow the …
genomic changes. Recent large-scale genomic data from prolonged infections allow the …
Convergent metabolic specialization through distinct evolutionary paths in Pseudomonas aeruginosa
Evolution by natural selection under complex and dynamic environmental conditions occurs
through intricate and often counterintuitive trajectories affecting many genes and metabolic …
through intricate and often counterintuitive trajectories affecting many genes and metabolic …