Polyamines are ubiquitous small basic molecules that play multiple essential roles in
mammalian physiology. Their cellular content is highly regulated and there is convincing …

Naturally occurring polyamines are ubiquitously distributed and play important roles in cell
development, amino acid and protein synthesis, oxidative DNA damage, proliferation, and …

Macrophage activation is a critical step in host responses during bacterial infections.
Ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine metabolism, has …

Pneumocystis jirovecii is the opportunistic fungal organism that causes Pneumocystis
pneumonia (PCP) in humans. Similar to other opportunistic pathogens, Pneumocystis …

We have recently reported that mice deficient in the myeloid Src-family tyrosine kinases Hck,
Fgr, and Lyn (Src triple knockout [TKO]) had augmented innate lung clearance of …

Myeloid-derived suppressor cells (MDSCs) were recently found to accumulate in the lungs
during Pneumocystis pneumonia (PcP). Adoptive transfer of these cells caused lung …

The intracellular levels of polyamines, cationic molecules involved in a myriad of cellular
functions ranging from cellular growth, differentiation and apoptosis, is precisely regulated …

BACKGROUND: Bacillus Calmette-Guérin (BCG) is a standard treatment to reduce tumor
recurrence and delay progression of high-risk non–muscle-invasive (NMI) bladder tumors …

Pneumocystis pneumonia (PcP) develops in immunocompromised patients. Alveolar
macrophages play a key role in the recognition, phagocytosis, and degradation of …

Limited data exist on the cytokine and cellular changes in the alveolar environment in
immunocompromised patients during Pneumocystis jirovecii infection. A cellular and a …