Enriched environments, experience-dependent plasticity and disorders of the nervous system

J Nithianantharajah, AJ Hannan - Nature Reviews Neuroscience, 2006 - nature.com
Behavioural, cellular and molecular studies have revealed significant effects of enriched
environments on rodents and other species, and provided new insights into mechanisms of …

The impact of environmental enrichment in laboratory rats—behavioural and neurochemical aspects

J Simpson, JP Kelly - Behavioural brain research, 2011 - Elsevier
The provision of environmental enrichment (EE) for laboratory rats is recommended in
European guidelines governing laboratory animal welfare. It is believed the EE …

Differential effect of environment enrichment and social isolation on depressive-like behavior, spontaneous activity and serotonin and norepinephrine concentration in …

JC Brenes, O Rodríguez, J Fornaguera - Pharmacology Biochemistry and …, 2008 - Elsevier
In order to determine the effect of postnatal environments on some behavioral and
neurochemical depressive-like parameters, male Sprague–Dawley rats were reared from …

A detailed analysis of open-field habituation and behavioral and neurochemical antidepressant-like effects in postweaning enriched rats

JC Brenes, M Padilla, J Fornaguera - Behavioural brain research, 2009 - Elsevier
Our previous work has shown that male Sprague–Dawley rats reared in social isolation,
standard housing and environmental enrichment differ in their spontaneous open-field …

Environmental enrichment produces a behavioral phenotype mediated by low cyclic adenosine monophosphate response element binding (CREB) activity in the …

TA Green, IN Alibhai, CN Roybal, CA Winstanley… - Biological …, 2010 - Elsevier
BACKGROUND: Previous research has shown that rats reared in an enriched condition
(EC) are more sensitive to the acute effects of amphetamine than rats reared in an isolated …

Altered serotonin receptor expression is associated with depression-related behavior in the R6/1 transgenic mouse model of Huntington's disease

TYC Pang, X Du, MS Zajac, ML Howard… - Human molecular …, 2009 - academic.oup.com
Dysregulation of the serotonergic signaling system has been implicated in the pathology of
mood disorders including depression, and various rodent models of disrupted serotonergic …

Environmental-enrichment–related variations in behavioral, biochemical, and physiologic responses of Sprague–Dawley and Long Evans rats

A Konkle, AC Kentner, SL Baker… - Journal of the …, 2010 - ingentaconnect.com
The behavioral, biochemical, and physiologic consequences of 6 wk of environmental
enrichment were evaluated in male Long Evans and Sprague–Dawley rats and compared …

Environmental enrichment and its influence on rodent offspring and maternal behaviours, a scoping style review of indices of depression and anxiety

JE Sparling, K Barbeau, K Boileau… - … Biochemistry and Behavior, 2020 - Elsevier
Environmental enrichment is a widely used experimental manipulation that consistently
shows measurable effects on rodent behaviour across the lifespan. This scoping review …

Environmental enrichment exerts sex-specific effects on emotionality in C57BL/6J mice

EJD Lin, E Choi, X Liu, A Martin, MJ During - Behavioural brain research, 2011 - Elsevier
Environmental enrichment (EE) has been shown to exert various behavioral and mood
effects in rodents including emotionality, which has a high propensity to be influenced by …

Enriched environments influence depression-related behavior in adult mice and the survival of newborn cells in their hippocampi

S Hattori, R Hashimoto, T Miyakawa… - Behavioural brain …, 2007 - Elsevier
Major depression is a highly prevalent mental disorder and environmental factors have been
strongly implicated in its pathophysiology. Clinical studies have demonstrated that stress or …