[HTML][HTML] Spatial multi-omics analyses of the tumor immune microenvironment

WC Hsieh, BR Budiarto, YF Wang, CY Lin… - Journal of Biomedical …, 2022 - Springer
In the past decade, single-cell technologies have revealed the heterogeneity of the tumor-
immune microenvironment at the genomic, transcriptomic, and proteomic levels and have …

[HTML][HTML] Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics

AH Merrill Jr - Chemical reviews, 2011 - ACS Publications
Much has been made about JLW Thudichum's colorful, and one could say clairvoyant,
naming of sphingosine “in commemoration of the many enigmas which it presented to the …

SEAM is a spatial single nuclear metabolomics method for dissecting tissue microenvironment

Z Yuan, Q Zhou, L Cai, L Pan, W Sun, S Qumu, S Yu… - Nature …, 2021 - nature.com
Spatial metabolomics can reveal intercellular heterogeneity and tissue organization. Here
we report on the spatial single nuclear metabolomics (SEAM) method, a flexible platform …

Mass spectrometric imaging for biomedical tissue analysis

K Chughtai, RMA Heeren - Chemical reviews, 2010 - ACS Publications
A mass spectrometer is described as the smallest weighing scale ever used in the world. 1
Mass spectrometry (MS) is a unique technique that has an interdisciplinary nature, which …

Imaging mass spectrometry

LA McDonnell, RMA Heeren - Mass spectrometry reviews, 2007 - Wiley Online Library
Imaging mass spectrometry combines the chemical specificity and parallel detection of mass
spectrometry with microscopic imaging capabilities. The ability to simultaneously obtain …

Ambient mass spectrometry using desorption electrospray ionization (DESI): instrumentation, mechanisms and applications in forensics, chemistry, and biology

Z Takats, JM Wiseman… - Journal of mass …, 2005 - Wiley Online Library
Analytical characteristics of DESI are summarized. Examples of applications to small and
large molecules, to in situ analysis, and to high‐throughput analyses are presented …

Sublimation as a method of matrix application for mass spectrometric imaging

JA Hankin, RM Barkley, RC Murphy - Journal of the American …, 2007 - ACS Publications
Common organic matrix-assisted laser desorption/ionization (MALDI) matrices, 2, 5-
dihydroxybenzoic acid, 3, 5-dimethoxy-4-hydroxycinnamic acid, and α-cyano-4 …

Advances in mass spectrometry for lipidomics

SJ Blanksby, TW Mitchell - Annual Review of Analytical …, 2010 - annualreviews.org
Recent expansion in research in the field of lipidomics has been driven by the development
of new mass spectrometric tools and protocols for the identification and quantification of …

Lipid imaging with time-of-flight secondary ion mass spectrometry (ToF-SIMS)

MK Passarelli, N Winograd - … et Biophysica Acta (BBA)-Molecular and Cell …, 2011 - Elsevier
Fundamental advances in secondary ion mass spectrometry (SIMS) now allow for the
examination and characterization of lipids directly from biological materials. The successful …

Sample preparation for mass spectrometry imaging: small mistakes can lead to big consequences

RJA Goodwin - Journal of proteomics, 2012 - Elsevier
Mass spectrometry imaging (MSI) enables the direct analysis of molecules from the surface
of a wide variety of samples, allowing the multiplex measurement of both abundance and …