In the past decade, single-cell technologies have revealed the heterogeneity of the tumor-
immune microenvironment at the genomic, transcriptomic, and proteomic levels and have …

Much has been made about JLW Thudichum's colorful, and one could say clairvoyant,
naming of sphingosine “in commemoration of the many enigmas which it presented to the …

Spatial metabolomics can reveal intercellular heterogeneity and tissue organization. Here
we report on the spatial single nuclear metabolomics (SEAM) method, a flexible platform …

A mass spectrometer is described as the smallest weighing scale ever used in the world. 1
Mass spectrometry (MS) is a unique technique that has an interdisciplinary nature, which …

Imaging mass spectrometry combines the chemical specificity and parallel detection of mass
spectrometry with microscopic imaging capabilities. The ability to simultaneously obtain …

Analytical characteristics of DESI are summarized. Examples of applications to small and
large molecules, to in situ analysis, and to high‐throughput analyses are presented …

Common organic matrix-assisted laser desorption/ionization (MALDI) matrices, 2, 5-
dihydroxybenzoic acid, 3, 5-dimethoxy-4-hydroxycinnamic acid, and α-cyano-4 …

Recent expansion in research in the field of lipidomics has been driven by the development
of new mass spectrometric tools and protocols for the identification and quantification of …

Fundamental advances in secondary ion mass spectrometry (SIMS) now allow for the
examination and characterization of lipids directly from biological materials. The successful …

Mass spectrometry imaging (MSI) enables the direct analysis of molecules from the surface
of a wide variety of samples, allowing the multiplex measurement of both abundance and …