Mode-of-action of antimicrobial peptides: membrane disruption vs. intracellular mechanisms
AH Benfield, ST Henriques - Frontiers in Medical Technology, 2020 - frontiersin.org
Antimicrobial peptides are an attractive alternative to traditional antibiotics, due to their
physicochemical properties, activity toward a broad spectrum of bacteria, and mode-of …
physicochemical properties, activity toward a broad spectrum of bacteria, and mode-of …
ZnO for performance enhancement of surface plasmon resonance biosensor: a review
This paper reviews Kretschmann-based SPR sensor utilizing ZnO thin films and
nanostructures for performance enhancement. The advancement in surface plasmon …
nanostructures for performance enhancement. The advancement in surface plasmon …
Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets
Containment of the COVID-19 pandemic requires reducing viral transmission. Severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is initiated by membrane fusion …
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is initiated by membrane fusion …
[HTML][HTML] Cyclic tachyplesin I kills proliferative, non-proliferative and drug-resistant melanoma cells without inducing resistance
AH Benfield, F Vernen, RSE Young, F Nadal-Bufí… - Pharmacological …, 2024 - Elsevier
Acquired drug resistance is the major cause for disease recurrence in cancer patients, and
this is particularly true for patients with metastatic melanoma that carry a BRAF V600E …
this is particularly true for patients with metastatic melanoma that carry a BRAF V600E …
RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome–associated cardiac hypertrophy
A Cuevas-Navarro, M Wagner, R Van, M Swain… - Science …, 2023 - science.org
RIT1 is a RAS guanosine triphosphatase (GTPase) that regulates different aspects of signal
transduction and is mutated in lung cancer, leukemia, and in the germline of individuals with …
transduction and is mutated in lung cancer, leukemia, and in the germline of individuals with …
Molecular dynamics simulation of small molecules interacting with biological membranes
C Martinotti, L Ruiz‐Perez, E Deplazes… - …, 2020 - Wiley Online Library
Cell membranes protect and compartmentalise cells and their organelles. The semi‐
permeable nature of these membranes controls the exchange of solutes across their …
permeable nature of these membranes controls the exchange of solutes across their …
Goldilocks Dilemma: LPS Works Both as the Initial Target and a Barrier for the Antimicrobial Action of Cationic AMPs on E. coli
Antimicrobial peptides (AMPs) are generally membrane-active compounds that physically
disrupt bacterial membranes. Despite extensive research, the precise mode of action of …
disrupt bacterial membranes. Despite extensive research, the precise mode of action of …
Enhancing the Intrinsic Antiplasmodial Activity and Improving the Stability and Selectivity of a Tunable Peptide Scaffold Derived from Human Platelet Factor 4
The control of malaria, a disease caused by Plasmodium parasites that kills over half a
million people every year, is threatened by the continual emergence and spread of drug …
million people every year, is threatened by the continual emergence and spread of drug …
Quantitative biophysical analysis defines key components modulating recruitment of the GTPase KRAS to the plasma membrane
B Lakshman, S Messing, EM Schmid… - Journal of Biological …, 2019 - ASBMB
The gene encoding the GTPase KRAS is frequently mutated in pancreatic, lung, and
colorectal cancers. The KRAS fraction in the plasma membrane (PM) correlates with …
colorectal cancers. The KRAS fraction in the plasma membrane (PM) correlates with …
RASopathy mutations provide functional insight into the BRAF cysteine-rich domain and reveal the importance of autoinhibition in BRAF regulation
R Spencer-Smith, EM Terrell, C Insinna, C Agamasu… - Molecular cell, 2022 - cell.com
BRAF is frequently mutated in human cancer and the RASopathy syndromes, with
RASopathy mutations often observed in the cysteine-rich domain (CRD). Although the CRD …
RASopathy mutations often observed in the cysteine-rich domain (CRD). Although the CRD …