Cellular viability requires tight regulation of actin cytoskeletal dynamics. Distinct families of
nucleation-promoting factors enable the rapid assembly of filament nuclei that elongate and …

The assembly of actin-based structures with precisely defined architectures supports
essential cellular functions, including motility, intracellular transport, and division. The …

During clathrin-mediated endocytosis in yeast cells, short actin filaments (< 200nm) and
crosslinking protein fimbrin assemble to drive the internalization of the plasma membrane …

The ability of adherent cells to form adhesions is critical to numerous phases of their
physiology. The assembly of adhesions is mediated by several types of integrins. These …

In cells, actin-binding proteins (ABPs) sort to different regions to establish F-actin networks
with diverse functions, including filopodia used for cell migration and contractile rings …

Bundles of actin filaments are central to a large variety of cellular structures such as
filopodia, stress fibers, cytokinetic rings, and focal adhesions. The mechanical properties of …

Cells polarize for growth, motion, or mating through regulation of membrane-bound small
GTPases between active GTP-bound and inactive GDP-bound forms. Activators (GEFs, GTP …

A key factor of actin cytoskeleton organization in cells is the interplay between the dynamical
properties of actin filaments and cell geometry, which restricts, confines and directs their …

Many actin structures are nucleated and assembled by the barbed‐end tracking polymerase
formin family, including filopodia, focal adhesions, the cytokinetic ring and cell cortex. These …

Remodeling of the actin cytoskeleton drives essential cell processes like morphogenesis,
motility, and cytokinesis. A network of actin-binding proteins tightly regulates each stage of …