Mechanisms of formin-mediated actin assembly and dynamics
N Courtemanche - Biophysical reviews, 2018 - Springer
Cellular viability requires tight regulation of actin cytoskeletal dynamics. Distinct families of
nucleation-promoting factors enable the rapid assembly of filament nuclei that elongate and …
nucleation-promoting factors enable the rapid assembly of filament nuclei that elongate and …
Cooperative bundling by fascin generates actin structures with architectures that depend on filament length
LA Sherer, N Courtemanche - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
The assembly of actin-based structures with precisely defined architectures supports
essential cellular functions, including motility, intracellular transport, and division. The …
essential cellular functions, including motility, intracellular transport, and division. The …
Structural organization and energy storage in crosslinked actin assemblies
During clathrin-mediated endocytosis in yeast cells, short actin filaments (< 200nm) and
crosslinking protein fimbrin assemble to drive the internalization of the plasma membrane …
crosslinking protein fimbrin assemble to drive the internalization of the plasma membrane …
Multiscale model of integrin adhesion assembly
The ability of adherent cells to form adhesions is critical to numerous phases of their
physiology. The assembly of adhesions is mediated by several types of integrins. These …
physiology. The assembly of adhesions is mediated by several types of integrins. These …
Mechanical and kinetic factors drive sorting of F-actin cross-linkers on bundles
SL Freedman, C Suarez… - Proceedings of the …, 2019 - National Acad Sciences
In cells, actin-binding proteins (ABPs) sort to different regions to establish F-actin networks
with diverse functions, including filopodia used for cell migration and contractile rings …
with diverse functions, including filopodia used for cell migration and contractile rings …
Force production by a bundle of growing actin filaments is limited by its mechanical properties
Bundles of actin filaments are central to a large variety of cellular structures such as
filopodia, stress fibers, cytokinetic rings, and focal adhesions. The mechanical properties of …
filopodia, stress fibers, cytokinetic rings, and focal adhesions. The mechanical properties of …
Fission yeast polarization: Modeling Cdc42 oscillations, symmetry breaking, and zones of activation and inhibition
B Khalili, HD Lovelace, DM Rutkowski, D Holz… - Cells, 2020 - mdpi.com
Cells polarize for growth, motion, or mating through regulation of membrane-bound small
GTPases between active GTP-bound and inactive GDP-bound forms. Activators (GEFs, GTP …
GTPases between active GTP-bound and inactive GDP-bound forms. Activators (GEFs, GTP …
Organization of associating or crosslinked actin filaments in confinement
M Adeli Koudehi, DM Rutkowski, D Vavylonis - Cytoskeleton, 2019 - Wiley Online Library
A key factor of actin cytoskeleton organization in cells is the interplay between the dynamical
properties of actin filaments and cell geometry, which restricts, confines and directs their …
properties of actin filaments and cell geometry, which restricts, confines and directs their …
Computational simulation of formin‐mediated actin polymerization predicts homologue‐dependent mechanosensitivity
D Bryant, L Clemens, J Allard - Cytoskeleton, 2017 - Wiley Online Library
Many actin structures are nucleated and assembled by the barbed‐end tracking polymerase
formin family, including filopodia, focal adhesions, the cytokinetic ring and cell cortex. These …
formin family, including filopodia, focal adhesions, the cytokinetic ring and cell cortex. These …
Interdependence of Nucleation, Elongation, and Bundling in the Assembly of Crosslinked Actin Structures
LA Sherer - 2022 - search.proquest.com
Remodeling of the actin cytoskeleton drives essential cell processes like morphogenesis,
motility, and cytokinesis. A network of actin-binding proteins tightly regulates each stage of …
motility, and cytokinesis. A network of actin-binding proteins tightly regulates each stage of …