Mitochondrial oxidative phosphorylation is incompletely coupled, since protons translocated
to the intermembrane space by specific respiratory complexes of the electron transport chain …

Mitochondrial reactive oxygen species (ROS) production and detoxification are tightly
balanced. Shifting this balance enables ROS to activate intracellular signaling and/or induce …

Altered mitochondrial metabolism is the underlying basis for the increased sensitivity in the
aged heart to stress. The aged heart exhibits impaired metabolic flexibility, with a decreased …

There are multiple sources of reactive oxygen species (ROS) in the cell. As a major site of
ROS production, mitochondria have drawn considerable interest because it was recently …

Redox-dependent processes influence most cellular functions, such as differentiation,
proliferation, and apoptosis. Mitochondria are at the center of these processes, as …

Mitochondria are a quantitatively relevant source of reactive oxygen species (ROS) in the
majority of cell types. Here we review the sources and metabolism of ROS in this organelle …

The generation of reactive oxygen species (ROS) is a fundamental aspect of normal human
biology. However, when ROS generation exceeds endogenous antioxidant capacity …

Alzheimer's disease (AD) is a debilitating neurodegenerative disorder characterized by the
progressive loss of cholinergic neurons, leading to the onset of severe behavioral, motor …

OBJECTIVE—In obesity and diabetes, myocardial fatty acid utilization and myocardial
oxygen consumption (M Vo 2) are increased, and cardiac efficiency is reduced …

While it is generally accepted that mitochondrial reactive oxygen species (ROS) balance
depends on the both rate of single electron reduction of O2 to superoxide (O2−) by the …