Serotonin reuptake inhibitor antidepressants, including selective serotonin reuptake
inhibitors (SSRIs; ie, citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and …

Over the past decade, considerable advances have been made in understanding genetic
influences on eating pathology. Eating disorders aggregate in families, and twin studies …

Interindividual differences in drug disposition are important causes for adverse drug
reactions and lack of drug response. The majority of phase I and phase II drug-metabolizing …

Introduction: The frequency of CYP2D6 alleles, related to either a lack of or increased
enzymatic activity, which may lead to poor metabolism (PM) or ultrarapid metabolism (UM) …

Transcription regulatory networks governing the genesis, maturation and maintenance of
vertebrate brain serotonin (5-HT) neurons determine the level of serotonergic gene …

CYP2D6, one of the major cytochrome P450 isoforms present in the human brain, is
associated with the incidence and prevalence of central nervous system (CNS) diseases …

Objectives: More than 40 drugs are available to treat affective disorders. Individual selection
of the optimal drug and dose is required to attain the highest possible efficacy and …

Pharmacogenomics represents a potentially powerful enhancement to the current standard
of care for psychiatric patients. However, a variety of biological and technical challenges …

Quantitative systems pharmacology (QSP) has emerged as a transformative science in drug
discovery and development. It is now time to fully rethink the biological functions of drug …

Selective serotonin reuptake inhibitors, tricyclic antidepressants, various psychoactive
drugs, as well as endogenous steroids and cannabinoid-like compounds are metabolized …