Questions Do magnetic resonance imaging (MRI) findings predict future low back pain
(LBP), associated disability and global recovery in people with current LBP? Do MRI …

Low back pain (LBP) has been among the leading causes of disability for the past 30 years.
This highlights the need for improvement in LBP management. Many clinical trials focus on …

Abstract Purpose Lumbar Modic change (MC) can serve as a diagnostic marker as well as
an independent source of chronic low back pain (CLBP). This study aimed to test for the …

The aim of this study was to evaluate the effect of zoledronic acid (ZA) and denosumab on
low back pain (LBP) and Modic change (MC) over 6 months. Adults aged≥ 40 years with …

Vertebral endplate bone marrow lesions, visualized on magnetic resonance imaging (MRI)
as Modic changes (MC), are associated with chronic low back pain (cLBP). Since guidelines …

Background In absence of uniform therapeutic recommendations, knowledge of the
available treatment options for Modic changes (MCs) patients and their safety and …

Objective Mechanical failure and inflammatory response are two mechanisms proposed for
the development of Modic changes, even though they have not been clearly demonstrated …

Background Limited reliability data exist for evaluation of spinal edema changes on
magnetic resonance imaging (MRI) with short tau inversion recovery (STIR) sequences …

The aim of the current study was to compare changes in serum biomarkers, including
inflammatory mediators, signaling molecules, growth factors and markers of bone turnover …

Background: Modic changes (MCs) associated with low back pain (LBP) have been
assessed in a few studies. It has been documented that patients with LBP have MCs in a …