One hundred years have passed since Warburg discovered alterations in cancer
metabolism, more than 70 years since Sidney Farber introduced anti-folates that …

During decades, the research field of cancer metabolism was based on the Warburg effect,
described almost one century ago. Lately, the key role of mitochondria in cancer …

Cancer cells alter metabolic processes to sustain their characteristic uncontrolled growth
and proliferation. These metabolic alterations include (1) a shift from oxidative …

Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …

Cancer cells characterized by uncontrolled growth and proliferation require altered
metabolic processes to maintain this characteristic. Metabolic reprogramming is a process …

Highlights•Cellular metabolism is reprogrammed to support tumorigenesis.•Folate fulfill
many metabolic requirements of proliferating cells and relevant metabolic pathway affect …

Metabolic pathways leading to the synthesis, uptake, and usage of the nonessential amino
acid serine are frequently amplified in cancer. Serine encounters diverse fates in cancer …

The serine-glycine-one-carbon (SGOC) metabolic pathway is critical for DNA methylation,
histone methylation, and redox homeostasis, in addition to protein, lipid, and nucleotide …

Burkitt lymphoma (BL) is an aggressive lymphoma type that is currently treated by intensive
chemoimmunotherapy. Despite the favorable clinical outcome for most patients with BL …

Abstract One-carbon (1C) metabolism encompasses folate-mediated 1C transfer reactions
and related processes, including nucleotide and amino acid biosynthesis, antioxidant …