The amyloid cascade hypothesis has always been a research focus in the therapeutic field
of Alzheimer's disease (AD) since it was put forward. Numerous researchers attempted to …

The human brain vasculature is of great medical importance: its dysfunction causes
disability and death, and the specialized structure it forms—the blood–brain barrier …

This literature review investigates the significant overlap between myelin-repair signaling
pathways and pathways known to contribute to hallmark pathologies of Alzheimer's disease …

Alzheimer's disease (AD) is characterized as a distinct onset and progression of cognitive
and functional decline associated with age, as well as a specific neuropathology. It has been …

Background Alzheimer's disease (AD) is a neurodegenerative disorder and the predominant
type of dementia worldwide. It is characterized by the progressive and irreversible decline of …

Osteopontin (OPN) is a multifunctional noncollagenous matrix phosphoprotein that is
expressed both intracellularly and extracellularly in various tissues. As a growth regulatory …

Background Alzheimer's disease (AD) is a progressive, chronic, and neurodegenerative
disease, and the most common cause of dementia worldwide. Currently, the mechanisms …

The pathogenesis of Alzheimer's disease (AD) remains unknown till today, hindering the
research and development of AD therapeutics and diagnostics. Circulating extracellular …

Developmental signalling pathways such as Wnt/β-catenin, Notch and Sonic hedgehog play
a central role in nearly all the stages of neuronal development. The term 'embryonic'might …

The presenilin-1 (PSEN1) gene is crucial in developing Alzheimer's disease (AD), a
progressive neurodegenerative disorder and the most common cause of dementia. Circular …