Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …

With recent rapid progress in research on aging, there is increasing evidence that many
features commonly considered to be mechanisms or drivers of aging in fact represent …

Chimeric antigen receptor (CAR) T cell therapy is revolutionizing cancer immunotherapy for
patients with B cell malignancies and is now being developed for solid tumors and chronic …

Acute myeloid leukaemia (AML) represents a set of heterogeneous myeloid malignancies,
and hallmarks include mutations in epigenetic modifiers, transcription factors and kinases …

Somatic mutations in cancer genes have been detected in clonal expansions across healthy
human tissue, including in clonal hematopoiesis. However, because mutated and wild-type …

The leukemia stem cell (LSC) compartment is a complex reservoir fueling disease
progression in acute myeloid leukemia (AML). The existence of heterogeneity within this …

The functional decline in T cells during their chronic stimulation, commonly referred to as T
cell exhaustion, is a major limitation for current immunotherapy approaches. As modern …

Germline pathogenic variants in DNMT3A were recently described in patients with
overgrowth, obesity, behavioral, and learning difficulties (D NMT3A O vergrowth S …

Pediatric myelodysplastic syndromes (MDS) often raise concern for an underlying germline
predisposition to hematologic malignancies, referred to as germline predisposition herein …

In the last decade, large-scale genomic studies in patients with hematologic malignancies
identified recurrent somatic alterations in epigenetic modifier genes. Among these, the de …