Neutrophils, the most prevalent innate immune cells in humans, have garnered significant
attention in recent years due to their involvement in cancer progression. This comprehensive …

Pancreatic cancer (PC) is one of the most lethal malignancies, which is generally resistant to
various treatments. Tumor angiogenesis is deemed to be a pivotal rate-determining step for …

Background: Neutrophils and Lipocalin-2 (LCN2) play pivotal roles in cerebral
ischemiareperfusion (I/R) injury. However, their contribution is not fully clarified. Objective …

Background: Patients with pancreatic ductal adenocarcinoma (PDAC) are increasingly
receiving systemic neoadjuvant chemotherapy (NAC), particularly those with borderline …

Pancreatic cancer is a major cause of cancer-related death, but despondently, the outlook
and prognosis for this resistant type of tumor have remained grim for a long time. Currently, it …

The immune system in humans is a defense department against both exogenous and
endogenous hazards, where CD8+ T cells play a crucial role in opposing pathological …

Purpose This review aims to provide an overview of the multiple functions of neutrophils,
with the recognition of the inflammatory (N1) and regenerative (N2) phenotypes, in relation …

Abstract Interleukin 35 (IL-35) is a newly discovered inhibitory cytokine of the IL12 family.
More recently, IL-35 was found to be increased in the tumor microenvironment (TME) and …

Glioma is a malignant tumor of the central nervous system (CNS). Currently, effective
treatment options for gliomas are still lacking. Neutrophils, as an important member of the …

Background Breast cancer-related inflammation is critical in tumorigenesis, cancer
progression, and patient prognosis. Several inflammatory markers derived from peripheral …