Nucleolar organization and ribosomal DNA stability in response to DNA damage
S Boukoura, DH Larsen - Current Opinion in Cell Biology, 2024 - Elsevier
Eukaryotic nuclei are structured into sub-compartments orchestrating various cellular
functions. The nucleolus is the largest nuclear organelle: a biomolecular condensate with an …
functions. The nucleolus is the largest nuclear organelle: a biomolecular condensate with an …
Macromolecular condensation organizes nucleolar sub-phases to set up a pH gradient
Nucleoli are multicomponent condensates defined by coexisting sub-phases. We identified
distinct intrinsically disordered regions (IDRs), including acidic (D/E) tracts and K-blocks …
distinct intrinsically disordered regions (IDRs), including acidic (D/E) tracts and K-blocks …
Emergent microenvironments of nucleoli
In higher eukaryotes, the nucleolus harbors at least three sub-phases that facilitate multiple
functionalities including ribosome biogenesis. The three prominent coexisting sub-phases …
functionalities including ribosome biogenesis. The three prominent coexisting sub-phases …
The nucleolus: Coordinating stress response and genomic stability
K González-Arzola - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2024 - Elsevier
The perception that the nucleoli are merely the organelles where ribosome biogenesis
occurs is challenged. Only around 30% of nucleolar proteins are solely involved in …
occurs is challenged. Only around 30% of nucleolar proteins are solely involved in …
Did organs precede organisms in the origin of life?
Evolutionary processes acting on populations of organized molecules preceded the origin of
living organisms. These prebiotic entities were independently and repeatedly produced [ie …
living organisms. These prebiotic entities were independently and repeatedly produced [ie …
Untangling Zebrafish Genetic Annotation: Addressing Complexities and Nomenclature Issues in Orthologous Evaluation of TCOF1 and NOLC1
G Hill-Terán, J Petrich, ML Falcone Ferreyra… - Journal of Molecular …, 2024 - Springer
Treacher Collins syndrome (TCS) is a genetic disorder affecting facial development,
primarily caused by mutations in the TCOF1 gene. TCOF1, along with NOLC1, play …
primarily caused by mutations in the TCOF1 gene. TCOF1, along with NOLC1, play …
An RNA condensate model for the origin of life
JL Fine, AM Moses - arXiv preprint arXiv:2412.05396, 2024 - arxiv.org
The RNA World hypothesis predicts that self-replicating RNAs evolved before DNA
genomes and coded proteins. Despite widespread support for the RNA World, self …
genomes and coded proteins. Despite widespread support for the RNA World, self …
[HTML][HTML] Active RNA synthesis patterns nuclear condensates
Biomolecular condensates are membraneless compartments that organize biochemical
processes in cells. In contrast to well-understood mechanisms describing how condensates …
processes in cells. In contrast to well-understood mechanisms describing how condensates …
Multivalent 28S rRNA Is the Organizer of the Nucleolus's Multi-layered Architecture
J Wei, Y Zhang, B Ye, X Fan, Y Hu, SQ Xiang, W Ma - bioRxiv, 2024 - biorxiv.org
The nucleolus widely exists in all eukaryotic species. Throughout evolution, two types of
nucleoli have emerged: bipartite, which has two-layered subcompartments, and tripartite …
nucleoli have emerged: bipartite, which has two-layered subcompartments, and tripartite …