The pharmacology of nitric oxide in the peripheral nervous system of blood vessels

N Toda, T Okamura - Pharmacological reviews, 2003 - ASPET
Unanticipated, novel hypothesis on nitric oxide (NO) radical, an inorganic, labile, gaseous
molecule, as a neurotransmitter first appeared in late 1989 and into the early 1990s, and …

Nitric oxide and penile erectile function

N Toda, K Ayajiki, T Okamura - Pharmacology & therapeutics, 2005 - Elsevier
The discovery of nitric oxide (NO) as an intercellular messenger or neurotransmitter opened
a new era for identifying the important mechanisms underlying physiological and …

Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: enhancement by angiotensin II

PJ Pagano, JK Clark… - Proceedings of the …, 1997 - National Acad Sciences
Superoxide anion (O2−) plays a key role in the endogenous suppression of endothelium-
derived nitric oxide (NO) bioactivity and has been implicated in the development of …

Effects of virgin olive oil phenolics on scavenging of reactive nitrogen species and upon nitrergic neurotransmission

R de la Puerta, MEM Domı́nguez, V Ruı́z-Gutı́errez… - Life Sciences, 2001 - Elsevier
The major phenolics from the polar fraction of virgin olive oil (caffeic acid, oleuropein, tyrosol
and hydroxytyrosol) have well-established antioxidant activities but their effects on reactive …

Upregulation of p67 phox and gp91 phox in aortas from angiotensin II-infused mice

ME Cifuentes, FE Rey, OA Carretero… - American Journal of …, 2000 - journals.physiology.org
Although NAD (P) H oxidase-derived superoxide (O2−) is increased during the development
of angiotensin II (ANG II)-dependent hypertension, vascular regulation at the protein level …

Gastrointestinal function regulation by nitrergic efferent nerves

N Toda, AG Herman - Pharmacological reviews, 2005 - ASPET
Gastrointestinal (GI) smooth muscle responses to stimulation of the nonadrenergic
noncholinergic inhibitory nerves have been suggested to be mediated by polypeptides, ATP …

Interaction between superoxide anion and nitric oxide in the regulation of vascular endothelial function

DW Laight, AV Kaw, MJ Carrier… - British journal of …, 1998 - Wiley Online Library
Nitric oxide (NO)‐mediated, endothelium‐dependent vasodilator function in rat aortic
smooth muscle was investigated in an in vitro model of endogenous vascular superoxide …

Recovery by ascorbate of impaired nitric oxide-dependent relaxation resulting from oxidant stress in rat aorta

S Dudgeon, DP Benson, A MacKenzie… - British journal of …, 1998 - ncbi.nlm.nih.gov
Recovery by ascorbate of impaired nitric oxide-dependent relaxation resulting from oxidant
stress in rat aorta Page 1 Recovery by ascorbate of impaired nitric oxide-dependent …

Superoxide anions, free-radical scavengers, and nitrergic neurotransmission

A Gibson, E Lilley - General Pharmacology: The Vascular System, 1997 - Elsevier
1. There is now strong evidence that the L-arginine/nitric oxide (NO) pathway generates the
transmitter released from certain nonadrenergic, noncholinergic nerves that mediate smooth …

Antioxidant protection of NO‐induced relaxations of the mouse anococcygeus against inhibition by superoxide anions, hydroquinone and carboxy‐PTIO

E Lilley, A Gibson - British journal of pharmacology, 1996 - Wiley Online Library
1 The potential protective effect of several antioxidants [Cu/Zn superoxide dismutase (Cu/Zn
SOD), ascorbate, reduced glutathione (GSH), and α‐tocopherol (α‐TOC)] on relaxations of …