The central nucleus of the amygdala and the construction of defensive modes across the threat-imminence continuum

JM Moscarello, MA Penzo - Nature Neuroscience, 2022 - nature.com
In nature, animals display defensive behaviors that reflect the spatiotemporal distance of
threats. Laboratory-based paradigms that elicit specific defensive responses in rodents have …

Freeze for action: neurobiological mechanisms in animal and human freezing

K Roelofs - … Transactions of the Royal Society B …, 2017 - royalsocietypublishing.org
Upon increasing levels of threat, animals activate qualitatively different defensive modes,
including freezing and active fight-or-flight reactions. Whereas freezing is a form of …

From circuits to behaviour in the amygdala

PH Janak, KM Tye - Nature, 2015 - nature.com
The amygdala has long been associated with emotion and motivation, playing an essential
part in processing both fearful and rewarding environmental stimuli. How can a single …

[图书][B] Adaptive markets: Financial evolution at the speed of thought

A Lo - 2017 - degruyter.com
Half of all Americans have money in the stock market, yet economists can't agree on whether
investors and markets are rational and efficient, as modern financial theory assumes, or …

Overlapping brain circuits for homeostatic and hedonic feeding

MA Rossi, GD Stuber - Cell metabolism, 2018 - cell.com
Central regulation of food intake is a key mechanism contributing to energy homeostasis.
Many neural circuits that are thought to orchestrate feeding behavior overlap with the brain's …

Coming to terms with fear

JE LeDoux - Proceedings of the National Academy of …, 2014 - National Acad Sciences
The brain mechanisms of fear have been studied extensively using Pavlovian fear
conditioning, a procedure that allows exploration of how the brain learns about and later …

The birth, death and resurrection of avoidance: a reconceptualization of a troubled paradigm

JE LeDoux, J Moscarello, R Sears, V Campese - Molecular psychiatry, 2017 - nature.com
Research on avoidance conditioning began in the late 1930s as a way to use laboratory
experiments to better understand uncontrollable fear and anxiety. Avoidance was initially …

Evoked axonal oxytocin release in the central amygdala attenuates fear response

HS Knobloch, A Charlet, LC Hoffmann, M Eliava… - Neuron, 2012 - cell.com
The hypothalamic neuropeptide oxytocin (OT), which controls childbirth and lactation,
receives increasing attention for its effects on social behaviors, but how it reaches central …

Fear extinction as a model for translational neuroscience: ten years of progress

MR Milad, GJ Quirk - Annual review of psychology, 2012 - annualreviews.org
The psychology of extinction has been studied for decades. Approximately 10 years ago,
however, there began a concerted effort to understand the neural circuits of extinction of fear …

[图书][B] The emotional brain: The mysterious underpinnings of emotional life

JE LeDoux - 1998 - books.google.com
What happens in our brains to make us feel fear, love, hate, anger, joy? do we control our
emotions, or do they control us? Do animals have emotions? How can traumatic …