Natural killer (NK) cells, the large granular lymphocytes differentiated from the common
lymphoid progenitors, were discovered in early 1970's. They are members of innate …

Genetic studies of ankylosing spondylitis (AS) have, over the past decade, provided major
insights into the etiopathogenesis of the disease that have led to major therapeutic …

Ankylosing spondylitis (AS) is a common, highly heritable arthropathy, the pathogenesis of
which is poorly understood. The mechanism by which the main gene for the disease, HLA …

Ankylosing spondylitis (AS) is an inflammatory autoimmune disease. AS is a prototype form
of spondyloarthropathies (SpA). The precise etiology of AS has not been fully understood …

Ankylosing Spondylitis (AS) is a debilitating rheumatic disease that gives young adults a
severe form of arthritis with pain and stiffness in the axial skeleton. After the discovery of …

Ankylosing spondylitis (AS) is a chronic inflammatory disease of unknown etiology, though it
is considered an autoimmune disease. HLA‐B27 is the risk factor most often associated with …

The findings suggest that further genome-wide studies in large case–control cohorts are
likely to be very productive in this disease. The IL23R findings and subsequent …

The term spondyloarthritis (SpA) encompasses a group of chronic inflammatory diseases
with common features in terms of clinical presentation and genetic predisposition. SpA is …

The discovery of the association of HLA B27 with spondyloarthropathy led to more questions
than answers about the role of this gene in disease susceptibility. The realization that HLA …

In the last 20 years, the study of human natural killer (NK) cells has moved from the first
molecular characterizations of very few receptor molecules to the identification of a plethora …