Familial inheritance of drug abuse is composed of both genetic and environmental factors.
Additionally, epigenetic transgenerational inheritance may provide a means by which …

Liver fibrosis arises because prolonged injury combined with excessive scar deposition
within hepatic parenchyma arising from overactive wound healing response mediated by …

Epigenetic marks change during fetal development, adult life, and aging. Some changes
play an important role in the establishment and regulation of gene programs, but others …

Alcoholism is a complex psychiatric disorder that has a multifactorial etiology. Epigenetic
mechanisms are uniquely capable of accounting for the multifactorial nature of the disease …

Drosophila melanogaster has become a significant model organism for alcohol research. In
flies, a rich variety of behaviors can be leveraged for identifying genes affecting alcohol …

Alcohol is the most socially accepted addictive drug. Alcohol consumption is associated with
some health problems such as neurological, cognitive, behavioral deficits, cancer, heart …

Alcohol use disorder (AUD) exacts an immense toll on individuals, families, and society.
Genetic factors determine up to 60% of an individual's risk of developing problematic alcohol …

Background Alcohol abuse and alcoholism are significant public health problems, but the
genetic basis for individual variation in alcohol sensitivity remains poorly understood …

Ethanol tolerance is the first type of behavioral plasticity and neural plasticity that is induced
by ethanol intake, and yet its molecular and circuit bases remain largely unexplored. Here …

Acute ethanol inebriation causes neuroadaptive changes in behavior that favor increased
intake. Ethanol-induced alterations in gene expression, through epigenetic and other …