Cytotoxicity of dendrimers

A Janaszewska, J Lazniewska, P Trzepiński… - Biomolecules, 2019 - mdpi.com
Drug delivery systems are molecular platforms in which an active compound is packed into
or loaded on a biocompatible nanoparticle. Such a solution improves the activity of the …

[HTML][HTML] Dendrimers in the context of nanomedicine

AP Dias, S da Silva Santos, JV da Silva… - International journal of …, 2020 - Elsevier
Dendrimers are globular structures, presenting an initiator core, repetitive layers starting
radially from the core and terminal groups on the surface, resembling tree architecture …

Overcoming the blood–brain barrier. challenges and tricks for CNS drug delivery

LA Bors, F Erdő - Scientia Pharmaceutica, 2019 - mdpi.com
Treatment of certain central nervous system disorders, including different types of cerebral
malignancies, is limited by traditional oral or systemic administrations of therapeutic drugs …

Dendrimer-based drug delivery systems for brain targeting

Y Zhu, C Liu, Z Pang - Biomolecules, 2019 - mdpi.com
Human neuroscience has made remarkable progress in understanding basic aspects of
functional organization; it is a renowned fact that the blood–brain barrier (BBB) impedes the …

Nanotechnology-based drug delivery systems for Alzheimer's disease management: Technical, industrial, and clinical challenges

MM Wen, NS El-Salamouni, WM El-Refaie… - Journal of controlled …, 2017 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease with high prevalence in the
rapidly growing elderly population in the developing world. The currently FDA approved …

Dendrimers and hyperbranched structures for biomedical applications

E Pedziwiatr-Werbicka, K Milowska, V Dzmitruk… - European Polymer …, 2019 - Elsevier
The use of nanotechnology in biology and medicine has been marked by rapid progress of
these industries due to the emergence of new devices, supramolecular systems, structures …

siRNA drug delivery across the blood–brain barrier in Alzheimer's disease

MI Sajid, FS Sheikh, F Anis, N Nasim… - Advanced Drug Delivery …, 2023 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease with a few FDA-
approved drugs that provide modest symptomatic benefits and only two FDA-approved …

Dendrimer advances for the central nervous system delivery of therapeutics

L Xu, H Zhang, Y Wu - ACS chemical neuroscience, 2014 - ACS Publications
The effectiveness of noninvasive treatment for central nervous system (CNS) diseases is
generally limited by the poor access of therapeutic agents into the CNS. Most CNS drugs …

Dendritic glycopolymers based on dendritic polyamine scaffolds: view on their synthetic approaches, characteristics and potential for biomedical applications

D Appelhans, B Klajnert-Maculewicz… - Chemical Society …, 2015 - pubs.rsc.org
In this review we highlight the potential for biomedical applications of dendritic
glycopolymers based on polyamine scaffolds. The complex interplay of the molecular …

Nanotechnology-based drug delivery systems for targeting, imaging and diagnosis of neurodegenerative diseases

S Bozdağ Pehlivan - Pharmaceutical research, 2013 - Springer
Neurodegenerative disorders are becoming prevalent with the increasing age of the general
population. A number of difficulties have emerged for the potential treatment of …