Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Hydrogen sulfide can signal through 3 distinct mechanisms: 1) reduction and/or direct
binding of metalloprotein heme centers, 2) serving as a potent antioxidant through reactive …

In the past years, we have learnt that tumors co-evolve with their microenvironment, and that
the active interaction between cancer cells and stromal cells plays a pivotal role in cancer …

Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration
pathway, is an important mammalian enzyme in health and disease. Its biochemical …

Mesenchymal stem cells (MSCs) are pivotal to tissue homeostasis, repair, and regeneration
due to their potential for self-renewal, multilineage differentiation, and immune modulation …

Metabolism describes the life-sustaining chemical reactions in organisms that provide both
energy and building blocks for cellular survival and proliferation. Dysregulated metabolism …

The expression of the reverse transsulfuration enzyme cystathionine-β-synthase (CBS) is
markedly increased in many forms of cancer, including colorectal, ovarian, lung, breast and …

Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating
several cell functions of cancer cells. Several natural products modulate both oxidative …

Hydrogen sulfide (H2S) is an endogenous biologically active gas produced in mammalian
tissues. It plays a very critical role in many pathophysiological processes in the body. It can …

Hydrogen sulfide (H2S) has a long history as toxic gas and environmental hazard; inhibition
of cytochrome c oxidase (mitochondrial Complex IV) is viewed as a primary mode of its …