The relative evolutionary roles of adaptive and non-adaptive processes remain a central
question in population genetics. Resolution of this debate has been difficult as an …

Current procedures for inferring population history generally assume complete neutrality—
that is, they neglect both direct selection and the effects of selection on linked sites. We here …

Analyses of genetic variation in many taxa have established that neutral genetic diversity is
shaped by natural selection at linked sites. Whether the mode of selection is primarily the …

Author summary Across the human genome, there are large-scale fluctuations in genetic
diversity caused by the indirect effects of selection. This “linked selection signal” reflects the …

It is increasingly evident that natural selection plays a prominent role in shaping patterns of
diversity across the genome. The most commonly studied modes of natural selection are …

Castellano et al. provide the first comparison of the full distribution of fitness effects
(including deleterious, neutral but also beneficial mutations) in the great apes. The authors …

Research in ecology and evolution today often emphasizes an equilibrium view of
dynamical systems, to the point where historical explanations are largely ignored. Such …

Since its inception in 1973, the slightly deleterious model of molecular evolution, also known
as the nearly neutral theory of molecular evolution, remains a central model to explain the …

Interpreting the formation of genomic variation landscape, especially genomic regions with
elevated differentiation (ie islands), is fundamental to a better understanding of the genomic …

Inferring the effects of positive selection on genomes remains a critical step in characterizing
the ultimate and proximate causes of adaptation across species, and quantifying positive …