Abstract FAT atypical cadherin 1 (FAT1), which encodes a protocadherin, is one of the most
frequently mutated genes in human cancer. Over the past 20 years, the role of FAT1 in tissue …

Vascular smooth muscle cells (VSMCs) are normally quiescent and non-migratory,
regulating the contraction and relaxation of blood vessels to control the vascular tone. In …

FAT atypical cadherin 1 (FAT1) promotes glioblastoma (GBM) by promoting protumorigenic
inflammatory cytokine expression in tumor cells. However, tumors also have an …

Cytokine storm refers to the dysregulated production of inflammatory mediators leading to
hyperinflammation. They are often detrimental, and worsen the severity of COVID-19 and …

Objective Previous studies have revealed that FAT atypical cadherin 1 (FAT1) plays a tumor-
suppressive or oncogenic role in a context-dependent manner in various cancers. However …

Primary liver cancer is the sixth most frequently diagnosed cancer worldwide and the third
leading cause of cancer-related death. The majority of the primary liver cancer cases are …

Simple Summary Energy metabolism plays a central role in the liver. Therefore, metabolic
alterations in liver cancer are fundamental for the development of diagnostic screening and …

The atypical cadherin FAT1 function either as a pro or antitumorigenic in tumors of different
tissue origins. Our group previously demonstrated the protumorigenic nature of FAT1 …

Abstract FAT atypical cadherin 1 (FAT1) is among the most frequently mutated genes in
many types of cancer. Its highest mutation rate is found in head and neck squamous cell …

(1) Background: PTC124 (Ataluren) is an investigational drug for the treatment of nonsense
mutation-mediated genetic diseases. With the exception of the TP53 tumor suppressor gene …