Research into cardiac autonomic control has received great interest in the past 20 years,
and we are now at a critical juncture with regard to the clinical translation of the experimental …

Neuropeptide Y (NPY) is an abundant sympathetic co-transmitter, widely found in the central
and peripheral nervous systems and with diverse roles in multiple physiological processes …

Angiotensin II (AngII) is implicated in neuroinflammation, blood-brain barrier (BBB)
disruption, and autonomic dysfunction in hypertension. We have previously shown that …

Arterial hypertension affects≈ 1 billion people worldwide. It is associated with increased
morbidity and mortality and responsible for millions of deaths each year. Hypertension …

Aims ST-elevation myocardial infarction is associated with high levels of cardiac sympathetic
drive and release of the co-transmitter neuropeptide Y (NPY). We hypothesized that despite …

The nervous system and cardiovascular system develop in concert and are functionally
interconnected in both health and disease. This white paper focuses on the cellular and …

Purpose Cardiac autonomic dysfunction is one of the main pillars of cardiovascular
pathophysiology. The purpose of this review is to provide an overview of the current state of …

Hypertensive heart disease (HHD) remains a major global public health concern despite the
implementation of new approaches for the management of hypertensive patients. The …

Aims The co-transmitter neuropeptide-Y (NPY) is released during high sympathetic drive,
including ST-elevation myocardial infarction (STEMI), and can be a potent vasoconstrictor …

O-GlcNAcylation is a post-translational modification (PTM) that regulates a wide range of
cellular functions and has been associated with multiple metabolic diseases in various …