Brain metastases remain a major problem in patients with advanced non-small cell lung
cancer (NSCLC). The permeability of the blood–brain barrier (BBB) is highly increased …

Although KRAS and TP53 mutations are major drivers of pancreatic ductal adenocarcinoma
(PDAC), the incurable nature of this cancer still remains largely elusive. ARF6 and its …

Primary tumours, particularly from major solid organs, are able to disseminate into the blood
and lymphatic system and spread to distant sites. These secondary metastases to other …

Mutations in the KRAS gene and overexpression of protein products of the MYC and ARF6
genes occur frequently in cancer. Here, the inseparable relationships and cooperation of the …

Background Breast cancers show variations in the number and biological aggressiveness of
cancer stem cells that correlate with their clinico-prognostic and molecular heterogeneity …

Background Breast cancer is one of the most common malignant tumor in women. The high
metastatic characteristics cause a high mortality rate of breast cancer. Increasing number of …

Glioblastoma multiforme (GBM), the most aggressive and malignant glioma, has a poor
prognosis. Although patients with GBM are treated with surgery, chemotherapy, and …

Background Ovarian cancer is the third most common gynecological cancer in the world but
the leading cause of death among gynecological malignancies. Epithelial splicing regulatory …

The acquired chemoresistance during long term chemotherapy is one of the most important
factors to limit the application of Doxorubicin (Dox) on clinical treatment of hepatocellular …

Purpose: Because of disease heterogeneity, limited studies on effective chemotherapies
and therapeutic agents for advanced gastric cancer are available. Erythrocyte membrane …