TGF-β1-mediated exosomal lnc-MMP2-2 increases blood–brain barrier permeability via the miRNA-1207-5p/EPB41L5 axis to promote non-small cell lung cancer …
D Wu, S Deng, L Li, T Liu, T Zhang, J Li, Y Yu… - Cell death & …, 2021 - nature.com
Brain metastases remain a major problem in patients with advanced non-small cell lung
cancer (NSCLC). The permeability of the blood–brain barrier (BBB) is highly increased …
cancer (NSCLC). The permeability of the blood–brain barrier (BBB) is highly increased …
ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer
S Hashimoto, S Furukawa… - Proceedings of the …, 2019 - National Acad Sciences
Although KRAS and TP53 mutations are major drivers of pancreatic ductal adenocarcinoma
(PDAC), the incurable nature of this cancer still remains largely elusive. ARF6 and its …
(PDAC), the incurable nature of this cancer still remains largely elusive. ARF6 and its …
Brain vascular microenvironments in cancer metastasis
Primary tumours, particularly from major solid organs, are able to disseminate into the blood
and lymphatic system and spread to distant sites. These secondary metastases to other …
and lymphatic system and spread to distant sites. These secondary metastases to other …
KRAS, MYC, and ARF6: inseparable relationships cooperatively promote cancer malignancy and immune evasion
H Sabe - Cell Communication and Signaling, 2023 - Springer
Mutations in the KRAS gene and overexpression of protein products of the MYC and ARF6
genes occur frequently in cancer. Here, the inseparable relationships and cooperation of the …
genes occur frequently in cancer. Here, the inseparable relationships and cooperation of the …
Identification and clinical validation of a multigene assay that interrogates the biology of cancer stem cells and predicts metastasis in breast cancer: A retrospective …
S Pece, D Disalvatore, D Tosoni, M Vecchi… - …, 2019 - thelancet.com
Background Breast cancers show variations in the number and biological aggressiveness of
cancer stem cells that correlate with their clinico-prognostic and molecular heterogeneity …
cancer stem cells that correlate with their clinico-prognostic and molecular heterogeneity …
LncRNA FOXD3-AS1 promotes breast cancer progression by mediating ARF6
X Zhang, X Zhao, L Chang, F Liu, C Li, P Ge - Breast Cancer, 2022 - Springer
Background Breast cancer is one of the most common malignant tumor in women. The high
metastatic characteristics cause a high mortality rate of breast cancer. Increasing number of …
metastatic characteristics cause a high mortality rate of breast cancer. Increasing number of …
ZBTB7A suppresses glioblastoma tumorigenesis through the transcriptional repression of EPB41L5
JH Jeong, SH Park, H Kim, HY Nam, SH Kim… - … & molecular medicine, 2023 - nature.com
Glioblastoma multiforme (GBM), the most aggressive and malignant glioma, has a poor
prognosis. Although patients with GBM are treated with surgery, chemotherapy, and …
prognosis. Although patients with GBM are treated with surgery, chemotherapy, and …
High expression of ESRP1 regulated by circ-0005585 promotes cell colonization in ovarian cancer
G Deng, X Zhou, L Chen, Y Yao, J Li, Y Zhang… - Cancer Cell …, 2020 - Springer
Background Ovarian cancer is the third most common gynecological cancer in the world but
the leading cause of death among gynecological malignancies. Epithelial splicing regulatory …
the leading cause of death among gynecological malignancies. Epithelial splicing regulatory …
ZEB1 mediates doxorubicin (Dox) resistance and mesenchymal characteristics of hepatocarcinoma cells
L Long, H Xiang, J Liu, Z Zhang, L Sun - Experimental and molecular …, 2019 - Elsevier
The acquired chemoresistance during long term chemotherapy is one of the most important
factors to limit the application of Doxorubicin (Dox) on clinical treatment of hepatocellular …
factors to limit the application of Doxorubicin (Dox) on clinical treatment of hepatocellular …
EPB41L5 mediates TGFβ-induced metastasis of gastric cancer
Purpose: Because of disease heterogeneity, limited studies on effective chemotherapies
and therapeutic agents for advanced gastric cancer are available. Erythrocyte membrane …
and therapeutic agents for advanced gastric cancer are available. Erythrocyte membrane …