Encapsulation and compartmentalization are fundamental to the evolution of cellular life, but
they also pose a challenge: how to partition the molecules that perform biological functions …

Dynamic hydrogen bonds and hydrogen-bond networks are ubiquitous in proteins and
protein complexes. Functional roles that have been assigned to hydrogen-bond networks …

Neuronal activity causes use-dependent decline in protein function. However, it is unclear
how this is coupled to local quality control mechanisms. We show in Drosophila that the …

Secretory preproteins of the Sec pathway are targeted post‐translationally and cross cellular
membranes through translocases. During cytoplasmic transit, mature domains remain non …

Sec secretory proteins are distinguished from cytoplasmic ones by N-terminal signal
peptides with multiple roles during post-translational translocation. They contribute to …

Succinate dehydrogenase inhibitor fungicides (SDHIs) are frequently detected in the marine
environment. However, studies on the toxicity of SDHIs to marine organisms, Mytilus …

The plastid stroma-localized chaperone HSP90C plays a crucial role in maintaining optimal
proteostasis within chloroplasts and participates in protein translocation processes. While …

Secretory preproteins of the Sec pathway bear signal peptides and are targeted post-
translationally to cross the plasma membrane or ER through translocases. After …

Approximately 30% of the proteins in bacteria are exported to the cell surface. The export
process is crucial for bacterial growth and survival, protein biogenesis, membrane function …

Sec‐pathway is the main protein secretion pathway in prokaryotes and is essential for their
survival. The motor protein SecA is the main coordinator of the pathway in bacteria as it is …