Rules and tools to predict the splicing effects of exonic and intronic mutations
K Ohno, J Takeda, A Masuda - Wiley Interdisciplinary Reviews …, 2018 - Wiley Online Library
Development of next generation sequencing technologies has enabled detection of
extensive arrays of germline and somatic single nucleotide variations (SNVs) in human …
extensive arrays of germline and somatic single nucleotide variations (SNVs) in human …
Regulation of alternative splicing: more than just the ABCs
AE House, KW Lynch - Journal of Biological Chemistry, 2008 - ASBMB
Alternative pre-mRNA splicing, the differential inclusion or exclusion of portions of a nascent
transcript into the final protein-coding mRNA, is widely recognized to be a ubiquitous …
transcript into the final protein-coding mRNA, is widely recognized to be a ubiquitous …
[HTML][HTML] Splice site m6A methylation prevents binding of U2AF35 to inhibit RNA splicing
Summary The N 6-methyladenosine (m 6 A) RNA modification is used widely to alter the fate
of mRNAs. Here we demonstrate that the C. elegans writer METT-10 (the ortholog of mouse …
of mRNAs. Here we demonstrate that the C. elegans writer METT-10 (the ortholog of mouse …
Maintenance of muscle stem-cell quiescence by microRNA-489
Among the key properties that distinguish adult mammalian stem cells from their more
differentiated progeny is the ability of stem cells to remain in a quiescent state for prolonged …
differentiated progeny is the ability of stem cells to remain in a quiescent state for prolonged …
Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer
S Delaunay, F Rapino, L Tharun, Z Zhou… - Journal of Experimental …, 2016 - rupress.org
Quantitative and qualitative changes in mRNA translation occur in tumor cells and support
cancer progression and metastasis. Posttranscriptional modifications of transfer RNAs …
cancer progression and metastasis. Posttranscriptional modifications of transfer RNAs …
A Pan-Cancer Analysis of Transcriptome Changes Associated with Somatic Mutations in U2AF1 Reveals Commonly Altered Splicing Events
Although recurrent somatic mutations in the splicing factor U2AF1 (also known as U2AF35)
have been identified in multiple cancer types, the effects of these mutations on the cancer …
have been identified in multiple cancer types, the effects of these mutations on the cancer …
Mechanisms for U2AF to define 3′ splice sites and regulate alternative splicing in the human genome
The U2AF heterodimer has been well studied for its role in defining functional 3′ splice
sites in pre-mRNA splicing, but many fundamental questions still remain unaddressed …
sites in pre-mRNA splicing, but many fundamental questions still remain unaddressed …
FUBP1 is a general splicing factor facilitating 3′ splice site recognition and splicing of long introns
S Ebersberger, C Hipp, MM Mulorz, A Buchbender… - Molecular cell, 2023 - cell.com
Splicing of pre-mRNAs critically contributes to gene regulation and proteome expansion in
eukaryotes, but our understanding of the recognition and pairing of splice sites during …
eukaryotes, but our understanding of the recognition and pairing of splice sites during …
Dek modulates global intron retention during muscle stem cells quiescence exit
Adult stem cells are essential for tissue regeneration. However, the mechanisms underlying
the activation of quiescent adult stem cells remain elusive. Using skeletal muscle stem cells …
the activation of quiescent adult stem cells remain elusive. Using skeletal muscle stem cells …
Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF
Many cellular functions involve multi-domain proteins, which are composed of structurally
independent modules connected by flexible linkers. Although it is often well understood how …
independent modules connected by flexible linkers. Although it is often well understood how …