Transcription of the ribosomal RNA genes (rDNA) that encode the three largest ribosomal
RNAs (rRNA), is mediated by RNA Polymerase I (Pol I) and is a key regulatory step for …

Background AS1411 is a 26-mer G-rich DNA oligonucleotide that forms a variety of G-
quadruplex structures. It was identified based on its cancer-selective antiproliferative activity …

Circular RNAs (circRNAs) are widely expressed in animal cells, but their biogenesis and
functions are poorly understood. CircRNAs have been shown to act as sponges for miRNAs …

A hexanucleotide repeat expansion (HRE),(GGGGCC) n, in C9orf72 is the most common
genetic cause of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and …

The biosynthesis of ribosomes is a complex process that requires the coordinated action of
many factors and a huge energy investment from the cell. Ribosomes are essential for …

Nucleolin (NCL) is a multifunctional protein that mainly localized in the nucleolus, it is also
found in the nucleoplasm, cytoplasm and cell membrane. The three main structural domains …

Background DNA aptamers represent a novel strategy in anti-cancer medicine. AS1411, a
DNA aptamer targeting nucleolin (a protein which is overexpressed in many tumor types) …

The recently identified GGGGCC repeat expansion in the noncoding region of C9ORF72 is
the most common pathogenic mutation in patients with frontotemporal dementia (FTD) or …

Nucleolin (NCL) is one of the most abundant non ribosomal protein of the nucleolus where it
plays a central role in polymerase I transcription. NCL is also found outside of the nucleolus …

Nucleoli are multicomponent condensates defined by coexisting sub-phases. We identified
distinct intrinsically disordered regions (IDRs), including acidic (D/E) tracts and K-blocks …