Allergic inflammatory memory in human respiratory epithelial progenitor cells

J Ordovas-Montanes, DF Dwyer, SK Nyquist… - Nature, 2018 - nature.com
Barrier tissue dysfunction is a fundamental feature of chronic human inflammatory diseases
1. Specialized subsets of epithelial cells—including secretory and ciliated cells …

Epithelial origin of eosinophilic esophagitis

M Rochman, NP Azouz, ME Rothenberg - Journal of Allergy and Clinical …, 2018 - Elsevier
Eosinophilic esophagitis (EoE) is a chronic, allergen-driven inflammatory disease of the
esophagus characterized predominantly by eosinophilic inflammation, leading to …

DNA methylation biomarkers in asthma and rhinitis: are we there yet?

E Legaki, C Arsenis, S Taka… - Clinical and …, 2022 - Wiley Online Library
The study of epigenetics has improved our understanding of mechanisms underpinning
gene‐environment interactions and is providing new insights in the pathophysiology of …

DNA methylation in nasal epithelium, atopy, and atopic asthma in children: a genome-wide study

E Forno, T Wang, C Qi, Q Yan, CJ Xu… - The lancet Respiratory …, 2019 - thelancet.com
Background Epigenetic mechanisms could alter the airway epithelial barrier and ultimately
lead to atopic diseases such as asthma. We aimed to identify DNA methylation profiles that …

[HTML][HTML] Mechanistic insights into the antipruritic effects of lebrikizumab, an anti–IL-13 mAb

Y Miron, PE Miller, C Hughes, T Indersmitten… - Journal of Allergy and …, 2022 - Elsevier
Background Atopic dermatitis (AD) is a chronic, inflammatory skin disease with persistent
and severe itch among its hallmark features. Significant increases in type 2 cytokines (ie, IL …

A transcriptomic method to determine airway immune dysfunction in T2-high and T2-low asthma

MC Peters, L Ringel, N Dyjack, R Herrin… - American journal of …, 2019 - atsjournals.org
Background: Type 2 (T2) inflammation drives airway dysfunction in many patients with
asthma; yet, we lack a comprehensive understanding of the airway immune cell types and …

Interleukin-13 in asthma and other eosinophilic disorders

E Doran, F Cai, CTJ Holweg, K Wong, J Brumm… - Frontiers in …, 2017 - frontiersin.org
Asthma is characterized by episodic, reversible airflow obstruction associated with variable
levels of inflammation. Over the past several decades, there has been an increasing …

Nasal DNA methylation profiling of asthma and rhinitis

C Qi, Y Jiang, IV Yang, E Forno, T Wang… - Journal of allergy and …, 2020 - Elsevier
Background Epigenetic signatures in the nasal epithelium, which is a primary interface with
the environment and an accessible proxy for the bronchial epithelium, might provide insights …

TSLP signaling in CD4+ T cells programs a pathogenic T helper 2 cell state

Y Rochman, K Dienger-Stambaugh, PK Richgels… - Science …, 2018 - science.org
Pathogenic T helper 2 (TH2) cells, which produce increased amounts of the cytokines
interleukin-5 (IL-5) and IL-13, promote allergic disorders, including asthma. Thymic stromal …

Broad transcriptional response of the human esophageal epithelium to proton pump inhibitors

M Rochman, YM Xie, L Mack, JM Caldwell… - Journal of Allergy and …, 2021 - Elsevier
Background Proton pump inhibitors (PPIs) have been recognized as a primary treatment of
eosinophilic esophagitis (EoE), an allergic inflammatory disease of the esophageal mucosa …