Barrier tissue dysfunction is a fundamental feature of chronic human inflammatory diseases
1. Specialized subsets of epithelial cells—including secretory and ciliated cells …

Eosinophilic esophagitis (EoE) is a chronic, allergen-driven inflammatory disease of the
esophagus characterized predominantly by eosinophilic inflammation, leading to …

The study of epigenetics has improved our understanding of mechanisms underpinning
gene‐environment interactions and is providing new insights in the pathophysiology of …

Background Epigenetic mechanisms could alter the airway epithelial barrier and ultimately
lead to atopic diseases such as asthma. We aimed to identify DNA methylation profiles that …

Background Atopic dermatitis (AD) is a chronic, inflammatory skin disease with persistent
and severe itch among its hallmark features. Significant increases in type 2 cytokines (ie, IL …

Background: Type 2 (T2) inflammation drives airway dysfunction in many patients with
asthma; yet, we lack a comprehensive understanding of the airway immune cell types and …

Asthma is characterized by episodic, reversible airflow obstruction associated with variable
levels of inflammation. Over the past several decades, there has been an increasing …

Background Epigenetic signatures in the nasal epithelium, which is a primary interface with
the environment and an accessible proxy for the bronchial epithelium, might provide insights …

Pathogenic T helper 2 (TH2) cells, which produce increased amounts of the cytokines
interleukin-5 (IL-5) and IL-13, promote allergic disorders, including asthma. Thymic stromal …

Background Proton pump inhibitors (PPIs) have been recognized as a primary treatment of
eosinophilic esophagitis (EoE), an allergic inflammatory disease of the esophageal mucosa …