Organelle‐specific mechanisms in crosstalk between apoptosis and ferroptosis

P Wu, X Zhang, D Duan, L Zhao - Oxidative Medicine and …, 2023 - Wiley Online Library
Apoptosis has been extensively studied, whereas ferroptosis is a newly discovered form of
regulated cell death that involves iron‐dependent accumulations of lipid hydroperoxides …

Lysosomal membrane permeabilization as a cell death mechanism in cancer cells

A Serrano-Puebla, P Boya - Biochemical Society Transactions, 2018 - portlandpress.com
Lysosomes are acidic organelles that contain hydrolytic enzymes that mediate the
intracellular degradation of macromolecules. Damage of these organelles often results in …

Curcumin induces crosstalk between autophagy and apoptosis mediated by calcium release from the endoplasmic reticulum, lysosomal destabilization and …

A Moustapha, PA Pérétout, NE Rainey, F Sureau… - Cell Death …, 2015 - nature.com
Curcumin, a major active component of turmeric (Curcuma longa, L.), has anticancer effects.
In vitro studies suggest that curcumin inhibits cancer cell growth by activating apoptosis, but …

The HN protein of Newcastle disease virus induces cell apoptosis through the induction of lysosomal membrane permeabilization

Y Chen, S Zhu, T Liao, C Wang, J Han, Z Yang… - Plos …, 2024 - journals.plos.org
Lysosomes are acidic organelles that mediate the degradation and recycling of cellular
waste materials. Damage to lysosomes can cause lysosomal membrane permeabilization …

p53 regulates lysosomal membrane permeabilization as well as cytoprotective autophagy in response to DNA-damaging drugs

G Yamashita, N Takano, H Kazama, K Tsukahara… - Cell Death …, 2022 - nature.com
Lysosomes are single-membraned organelles that mediate the intracellular degradation of
macromolecules. Various stress can induce lysosomal membrane permeabilization (LMP) …

The inhibition of death receptor mediated apoptosis through lysosome stabilization following internalization of carboxyfullerene nanoparticles

W Li, L Zhao, T Wei, Y Zhao, C Chen - Biomaterials, 2011 - Elsevier
Cells undergo apoptosis through two major pathways, the extrinsic pathway (death receptor
pathway) and the intrinsic pathway (the mitochondrial pathway). It is well known that …

Mechanisms of cellular effects directly induced by magnetic nanoparticles under magnetic fields

L Chen, C Chen, P Wang, T Song - Journal of nanomaterials, 2017 - Wiley Online Library
The interaction of magnetic nanoparticles (MNPs) with various magnetic fields could directly
induce cellular effects. Many scattered investigations have got involved in these cellular …

In vitro and in vivo studies on potentiation of curcumin-induced lysosomal-dependent apoptosis upon silencing of cathepsin C in colorectal cancer cells

TP Khaket, MP Singh, I Khan, SC Kang - Pharmacological research, 2020 - Elsevier
Cathepsins are lysosomal acid hydrolases that make crucial contributions to tumor
progression through a variety of signaling mechanisms, including autophagy, cell survival …

Phosphatidic acid mediates the targeting of tBid to induce lysosomal membrane permeabilization and apoptosis

K Zhao, H Zhou, X Zhao, DW Wolff, Y Tu, H Liu… - Journal of lipid …, 2012 - ASBMB
Upon apoptotic stimuli, lysosomal proteases, including cathepsins and chymotrypsin, are
released into cytosol due to lysosomal membrane permeabilization (LMP), where they …

Europium-doped Gd2O3 nanotubes cause the necrosis of primary mouse bone marrow stromal cells through lysosome and mitochondrion damage

Y Jin, S Chen, J Duan, G Jia, J Zhang - Journal of inorganic biochemistry, 2015 - Elsevier
With the wide applications of europium-doped Gd 2 O 3 nanoparticles (Gd 2 O 3: Eu 3+ NPs)
in biomedical fields, it will inevitably increase the chance of human exposure. It was reported …