The RaPID platform for the discovery of pseudo-natural macrocyclic peptides
Y Goto, H Suga - Accounts of Chemical Research, 2021 - ACS Publications
Conspectus Although macrocyclic peptides bearing exotic building blocks have proven their
utility as pharmaceuticals, the sources of macrocyclic peptide drugs have been largely …
utility as pharmaceuticals, the sources of macrocyclic peptide drugs have been largely …
Translation in prokaryotes
MV Rodnina - Cold Spring Harbor perspectives in …, 2018 - cshperspectives.cshlp.org
This review summarizes our current understanding of translation in prokaryotes, focusing on
the mechanistic and structural aspects of each phase of translation: initiation, elongation …
the mechanistic and structural aspects of each phase of translation: initiation, elongation …
In vitro selection of macrocyclic peptide inhibitors containing cyclic γ2,4-amino acids targeting the SARS-CoV-2 main protease
Abstract γ-Amino acids can play important roles in the biological activities of natural
products; however, the ribosomal incorporation of γ-amino acids into peptides is …
products; however, the ribosomal incorporation of γ-amino acids into peptides is …
Translation elongation and recoding in eukaryotes
In this review, we highlight the current understanding of translation elongation and recoding
in eukaryotes. In addition to providing an overview of the process, recent advances in our …
in eukaryotes. In addition to providing an overview of the process, recent advances in our …
eIF5A functions globally in translation elongation and termination
The eukaryotic translation factor eIF5A, originally identified as an initiation factor, was later
shown to promote translation elongation of iterated proline sequences. Using a combination …
shown to promote translation elongation of iterated proline sequences. Using a combination …
Ribosomal synthesis and de novo discovery of bioactive foldamer peptides containing cyclic β-amino acids
Peptides that contain β-amino acids display stable secondary structures, such as helices
and sheets, and are often referred to as foldamers. Cyclic β2, 3-amino acids (cβAAs), such …
and sheets, and are often referred to as foldamers. Cyclic β2, 3-amino acids (cβAAs), such …
Cell-free gene expression: methods and applications
Cell-free gene expression (CFE) systems empower synthetic biologists to build biological
molecules and processes outside of living intact cells. The foundational principle is that …
molecules and processes outside of living intact cells. The foundational principle is that …
Structural basis for polyproline-mediated ribosome stalling and rescue by the translation elongation factor EF-P
Ribosomes synthesizing proteins containing consecutive proline residues become stalled
and require rescue via the action of uniquely modified translation elongation factors, EF-P in …
and require rescue via the action of uniquely modified translation elongation factors, EF-P in …
Ribosome-mediated polymerization of long chain carbon and cyclic amino acids into peptides in vitro
Ribosome-mediated polymerization of backbone-extended monomers into polypeptides is
challenging due to their poor compatibility with the translation apparatus, which evolved to …
challenging due to their poor compatibility with the translation apparatus, which evolved to …
In vitro genetic code reprogramming for the expansion of usable noncanonical amino acids
T Katoh, H Suga - Annual Review of Biochemistry, 2022 - annualreviews.org
Genetic code reprogramming has enabled us to ribosomally incorporate various
nonproteinogenic amino acids (npAAs) into peptides in vitro. The repertoire of usable npAAs …
nonproteinogenic amino acids (npAAs) into peptides in vitro. The repertoire of usable npAAs …