Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB. T1

LM Holt, RD Hernandez, NL Pacheco, B Torres Ceja… - Elife, 2019 - elifesciences.org
Brain-derived neurotrophic factor (BDNF) is a critical growth factor involved in the maturation
of the CNS, including neuronal morphology and synapse refinement. Herein, we …

Control of RNA viruses in mosquito cells through the acquisition of vDNA and endogenous viral elements

M Tassetto, M Kunitomi, ZJ Whitfield, PT Dolan… - Elife, 2019 - elifesciences.org
Aedes aegypti transmit pathogenic arboviruses while the mosquito itself tolerates the
infection. We examine a piRNA-based immunity that relies on the acquisition of viral derived …

Chimeric origins of ochrophytes and haptophytes revealed through an ancient plastid proteome

RG Dorrell, G Gile, G Mccallum, R Méheust… - elife, 2017 - elifesciences.org
Plastids are supported by a wide range of proteins encoded within the nucleus and imported
from the cytoplasm. These plastid-targeted proteins may originate from the endosymbiont …

Kadi4Mat: A research data infrastructure for materials science

N Brandt, L Griem, C Herrmann… - Data Science …, 2021 - account.datascience.codata.org
The concepts and current developments of a research data infrastructure for materials
science are presented, extending and combining the features of an electronic lab notebook …

ASH1-catalyzed H3K36 methylation drives gene repression and marks H3K27me2/3-competent chromatin

VT Bicocca, T Ormsby, KK Adhvaryu, S Honda… - Elife, 2018 - elifesciences.org
Methylation of histone H3 at lysine 36 (H3K36me), a widely-distributed chromatin mark,
largely results from association of the lysine methyltransferase (KMT) SET-2 with RNA …

Is it possible to reconstruct an accurate cell lineage using CRISPR recorders?

I Salvador-Martínez, M Grillo, M Averof, MJ Telford - Elife, 2019 - elifesciences.org
Cell lineages provide the framework for understanding how cell fates are decided during
development. Describing cell lineages in most organisms is challenging; even a fruit fly larva …

Keratin 14-dependent disulfides regulate epidermal homeostasis and barrier function via 14-3-3σ and YAP1

Y Guo, CJ Redmond, KA Leacock, MV Brovkina, S Ji… - Elife, 2020 - elifesciences.org
The intermediate filament protein keratin 14 (K14) provides vital structural support in basal
keratinocytes of epidermis. Recent studies evidenced a role for K14-dependent disulfide …

Transcriptomic and epigenetic regulation of hair cell regeneration in the mouse utricle and its potentiation by Atoh1

HI Jen, MC Hill, L Tao, K Sheng, W Cao, H Zhang… - Elife, 2019 - elifesciences.org
The mammalian cochlea loses its ability to regenerate new hair cells prior to the onset of
hearing. In contrast, the adult vestibular system can produce new hair cells in response to …

Metabolic interactions between dynamic bacterial subpopulations

AZ Rosenthal, Y Qi, S Hormoz, J Park, SHJ Li… - Elife, 2018 - elifesciences.org
Individual microbial species are known to occupy distinct metabolic niches within multi-
species communities. However, it has remained largely unclear whether metabolic …

Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells

JP Russell, X Lim, A Santambrogio, V Yianni… - Elife, 2021 - elifesciences.org
In response to physiological demand, the pituitary gland generates new hormone-secreting
cells from committed progenitor cells throughout life. It remains unclear to what extent …