The emerging roles of TERRA in telomere maintenance and genome stability
N Bettin, C Oss Pegorar, E Cusanelli - Cells, 2019 - mdpi.com
The finding that transcription occurs at chromosome ends has opened new fields of study on
the roles of telomeric transcripts in chromosome end maintenance and genome stability …
the roles of telomeric transcripts in chromosome end maintenance and genome stability …
Expanding the role of the histone lysine-specific demethylase LSD1 in cancer
Studies of alterations in histone methylation in cancer have led to the identification of histone
methyltransferases and demethylases as novel targets for therapy. Lysine-specific …
methyltransferases and demethylases as novel targets for therapy. Lysine-specific …
Mechanism of crosstalk between the LSD1 demethylase and HDAC1 deacetylase in the CoREST complex
The transcriptional corepressor complex CoREST is one of seven histone deacetylase
complexes that regulate the genome through controlling chromatin acetylation. The CoREST …
complexes that regulate the genome through controlling chromatin acetylation. The CoREST …
Expression and differential regulation of human TERRA at several chromosome ends
M Feretzaki, PR Nunes, J Lingner - Rna, 2019 - rnajournal.cshlp.org
The telomeric long noncoding RNA TERRA has been implicated in regulating telomere
maintenance by telomerase and homologous recombination, and in influencing telomeric …
maintenance by telomerase and homologous recombination, and in influencing telomeric …
[HTML][HTML] Telomere-specific regulation of TERRA and its impact on telomere stability
J Rivosecchi, K Jurikova, E Cusanelli - Seminars in Cell & Developmental …, 2024 - Elsevier
TERRA is a class of telomeric repeat-containing RNAs that are expressed from telomeres in
multiple organisms. TERRA transcripts play key roles in telomere maintenance and their …
multiple organisms. TERRA transcripts play key roles in telomere maintenance and their …
Genome instability in multiple myeloma: Facts and factors
Simple Summary Multiple myeloma is an incurable blood cancer caused by the malignant
transformation of immunoglobulin-producing plasma cells. The mechanisms leading to the …
transformation of immunoglobulin-producing plasma cells. The mechanisms leading to the …
Histone lysine demethylase KDM4B regulates the alternative splicing of the androgen receptor in response to androgen deprivation
L Duan, Z Chen, J Lu, Y Liang, M Wang… - Nucleic acids …, 2019 - academic.oup.com
Alternative splicing is emerging as an oncogenic mechanism. In prostate cancer, generation
of constitutively active forms of androgen receptor (AR) variants including AR-V7 plays an …
of constitutively active forms of androgen receptor (AR) variants including AR-V7 plays an …
Structural and functional landscape of FAD-dependent histone lysine demethylases for new drug discovery
Small molecules targeting the flavin adenine dinucleotide (FAD)-dependent histone lysine
demethylase LSD family have displayed therapeutic promise against various diseases. Nine …
demethylase LSD family have displayed therapeutic promise against various diseases. Nine …
Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features
Because of its involvement in the progression of several malignant tumors, the histone lysine-
specific demethylase 1 (LSD1) has become a prominent drug target in modern medicinal …
specific demethylase 1 (LSD1) has become a prominent drug target in modern medicinal …
Telomeric chromatin and TERRA
A Barral, J Déjardin - Journal of molecular biology, 2020 - Elsevier
Chromatin function in telomeres is poorly understood, but it is generally viewed as
repressive. Yet, telomeric DNA sequences are transcribed into long non-coding RNAs …
repressive. Yet, telomeric DNA sequences are transcribed into long non-coding RNAs …