Normal cells explore multiple states to survive stresses encountered during development
and self-renewal as well as environmental stresses such as starvation, DNA damage, toxins …

In vertebrate cells, the DNA damage response is controlled by three related kinases: ATM,
ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be …

Combination of anti-cancer drugs is broadly seen as way to overcome the often-limited
efficacy of single agents. The design and testing of combinations are however very …

High-fidelity DNA replication is critical for the faithful transmission of genetic information to
daughter cells. Following genotoxic stress, specialized DNA damage tolerance pathways …

One way to preserve a rare book is to lock it away from all potential sources of damage. Of
course, an inaccessible book is also of little use, and the paper and ink will continue to …

Innate lymphoid cells (ILCs) are innate counterparts of adaptive T lymphocytes, contributing
to host defense, tissue repair, metabolic homeostasis, and inflammatory diseases. ILCs have …

An underlying hallmark of cancers is their genomic instability, which is associated with a
greater propensity to accumulate DNA damage. Historical treatment of cancer by …

Predictive biomarkers of response are essential to effectively guide targeted cancer
treatment. Ataxia telangiectasia and Rad3-related kinase inhibitors (ATRi) have been shown …

Germline aberrations in critical DNA-repair and DNA damage–response (DDR) genes
cause cancer predisposition, whereas various tumors harbor somatic mutations causing …

DNA-dependent protein kinase (DNA-PK) is a critical player in the DNA damage response
(DDR) and instrumental in the non-homologous end-joining pathway (NHEJ) used to detect …