After being discovered from the bovine pineal gland by Aaron Lerner and co-workers in the
year 1958, various distinguished researchers have reported melatonin (5-methoxy-N-acetyl …

In vertebrates, melatonin (N-acetyl-5-methoxy-tryptamine, MEL) is synthesized from L-
tryptophan (L-Trp), primarily in the pineal gland and additionally in several non-pineal …

Hormones and neurotransmitters are essential to homeostasis, and their disruptions are
connected to diseases ranging from cancer to anxiety. The differential reactivation of …

Melatonin is synthesized in peripheral locations of vertebrates, including the gastrointestinal
tract (GIT). In teleost, information regarding this topic is scarce. Here we studied the …

Melatonin, a well-known neurohormone, was discovered in animal tissues in 1958. In plants,
its presence was detected in 1995, and its biosynthesis, from tryptophan, seems to follow …

Emerging studies have revealed that O-GlcNAcylation plays pivotal roles in the
tumorigenesis of colorectal cancers (CRCs). However, the underlying mechanism still …

Melatonin is an important component of the vertebrates circadian system, synthetized from
serotonin by the successive action of the arylalkylamine N‐acetyltransferase (Aanat …

Photoperiod plays an essential role in the synchronization of metabolism, physiology, and
behavior to the cyclic variations of the environment. In vertebrates, information is relayed by …

Melatonin is a pleiotropic substance that is widely distributed in all kingdoms. Discovered in
animals in 1958, this neurohormone is synthesized in the pineal gland and has multiple …

In vertebrates, arylalkylamine N‐acetyltransferase (AANAT; EC 2.3. 1.87) is the time‐
keeping and key regulatory enzyme in melatonin (Mel) biosynthesis. AANAT is present in …