The Mediator complex, which in humans is 1.4 MDa in size and includes 26 subunits,
controls many aspects of RNA polymerase II (Pol II) function. Apart from its size, a defining …

Alterations in the regulation of gene expression are frequently associated with
developmental diseases or cancer. Transcription activation is a key phenomenon in the …

A central question in biology is whether variability between genetically identical cells
exposed to the same culture conditions is largely stochastic or deterministic. Using image …

Nuclear pore complexes (NPCs) are important for cellular functions beyond
nucleocytoplasmic trafficking, including genome organization and gene expression. This …

TRanscription and EXport (TREX) is a conserved multisubunit complex essential for
embryogenesis, organogenesis and cellular differentiation throughout life. By linking …

Mediator is an essential, large, multisubunit, transcriptional co-activator highly conserved
across eukaryotes. Mediator interacts with gene-specific transcription factors at enhancers …

Unlike in metazoans, the stepwise biogenesis of microRNAs (miRNAs) in plants occurs
within the nucleus. Whether or how the major steps in miRNA biogenesis are coordinated is …

The nuclear basket attaches to the nucleoplasmic side of the nuclear pore complex (NPC),
coupling transcription to mRNA quality control and export. The basket expands the …

Nuclear pore complexes (NPCs) have increasingly recognized interactions with the
genome, as exemplified in yeast, where they bind transcribed or damaged chromatin. By …

The nuclear basket (NB) is an essential structure of the nuclear pore complex (NPC) and
serves as a dynamic and multifunctional platform that participates in various critical nuclear …