An insight on medicinal attributes of 1, 2, 4-triazoles
R Aggarwal, G Sumran - European journal of medicinal chemistry, 2020 - Elsevier
The present review aims to summarize the pharmacological profile of 1, 2, 4-triazole, one of
the emerging privileged scaffold, as antifungal, antibacterial, anticancer, anticonvulsant …
the emerging privileged scaffold, as antifungal, antibacterial, anticancer, anticonvulsant …
Novel approaches, drug candidates, and targets in pain drug discovery
Because of the problems associated with opioids, drug discovery efforts have been
employed to develop opioids with reduced side effects using approaches such as biased …
employed to develop opioids with reduced side effects using approaches such as biased …
[HTML][HTML] Cyclooxygenase-2 (COX-2) as a target of anticancer agents: A review of novel synthesized scaffolds having anticancer and COX-2 inhibitory potentialities
Cancer is a serious threat to human beings and is the second-largest cause of death all over
the globe. Chemotherapy is one of the most common treatments for cancer; however, drug …
the globe. Chemotherapy is one of the most common treatments for cancer; however, drug …
1,3,4-Oxadiazole-naphthalene hybrids as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative activity, apoptotic effect, and in silico studies
In the current work, some 1, 3, 4-oxadiazole-naphthalene hybrids were designed and
synthesised as VEGFR-2 inhibitors. The synthesised compounds were evaluated in vitro for …
synthesised as VEGFR-2 inhibitors. The synthesised compounds were evaluated in vitro for …
Selective COX-2 inhibitors as anticancer agents: a patent review (2014-2018)
SMI Mahboubi Rabbani, A Zarghi - Expert opinion on therapeutic …, 2019 - Taylor & Francis
Introduction: COX-2 is a key enzyme in the process of prostaglandins (PGs) synthesis. The
products of this enzyme could play a major role as the mediators of the inflammatory …
products of this enzyme could play a major role as the mediators of the inflammatory …
Synthesis, antitumor, and apoptosis-inducing activities of novel 5-arylidenethiazolidine-2, 4-dione derivatives: histone deacetylases inhibitory activity and molecular …
The antitumor activity of the newly synthesized 5-arylidenethiazolidine-2, 4-dione derivatives
18a–f and 19a–f was investigated, compared to doxorubicin (IC 50= 4.17–8.87 μM) and …
18a–f and 19a–f was investigated, compared to doxorubicin (IC 50= 4.17–8.87 μM) and …
Design and Development of COX-II Inhibitors: Current Scenario and Future Perspective
Innate inflammation beyond a threshold is a significant problem involved in cardiovascular
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …
Synthesis, cytotoxic evaluation, and molecular docking studies of novel quinazoline derivatives with benzenesulfonamide and anilide tails: Dual inhibitors of EGFR …
HM Alkahtani, AN Abdalla, AJ Obaidullah… - Bioorganic …, 2020 - Elsevier
We synthesized a new series of 2-[(3-(4-sulfamoylphenethyl)-4 (3H)-quinazolinon-2-yl) thio]
anilide derivatives (2–16) and evaluated their cytotoxic activity against breast …
anilide derivatives (2–16) and evaluated their cytotoxic activity against breast …
Design, synthesis, and antitumor activity of novel compounds based on 1, 2, 4-triazolophthalazine scaffold: apoptosis-inductive and PCAF-inhibitory effects
The antitumor activity of newly synthesised triazolophthalazines (L-45 analogues) 10–32
was evaluated in human hepatocellular carcinoma (HePG-2), breast cancer (MCF-7) …
was evaluated in human hepatocellular carcinoma (HePG-2), breast cancer (MCF-7) …
[HTML][HTML] Synthesis and investigation of anti-inflammatory activity of new thiourea derivatives of naproxen
N Nedeljković, V Dobričić, J Bošković, M Vesović… - Pharmaceuticals, 2023 - mdpi.com
The aim of the study was a synthesis and investigation of the dose-dependent anti-
inflammatory effect of new thiourea derivatives of naproxen with selected aromatic amines …
inflammatory effect of new thiourea derivatives of naproxen with selected aromatic amines …