In neurological diseases, the actions of microglia, the resident myeloid cells of the CNS
parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature
myeloid cells that suppress innate and adaptive immunity. MDSCs are present in many …

Controversy surrounds neutrophil function in cancer because neutrophils were shown to
provide both pro-and antitumor functions. We identified a heterogeneous subset of low …

Resolution of inflammation is a coordinated and active process aimed at restoration of tissue
integrity and function. This review integrates the key molecular and cellular mechanisms of …

Monocyte-derived myeloid cells play vital roles in inflammation-related autoimmune/
inflammatory diseases and cancers. Here, we report that exosomes can deliver anti …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that
expand during cancer, inflammation and infection, and that have a remarkable ability to …

Primary tumors have been shown to prepare distal organs for later colonization of metastatic
cells by stimulating organ-specific infiltration of bone marrow derived cells. Here we …

Arginine metabolism has been a key catabolic and anabolic process throughout the
evolution of the immune response. Accruing evidence indicates that arginine-catabolizing …

Many cancer immunotherapies developed in experimental animals have been tested in
clinical trials. Although some have shown modest clinical effects, most have not been …

Dimethyl fumarate (DMF)(BG-12, Tecfidera) is a fumaric acid ester (FAE) that was advanced
as a multiple sclerosis (MS) therapy largely for potential neuroprotection as it was …