Profiling pretomanid as a therapeutic option for TB infection: evidence to date
SL Stancil, F Mirzayev… - Drug Design …, 2021 - Taylor & Francis
Tuberculosis (TB) is the most deadly infectious disease globally. Although most individuals
achieve a cure, a substantial portion develop multi-drug resistant TB which is exceedingly …
achieve a cure, a substantial portion develop multi-drug resistant TB which is exceedingly …
Oxazolidinones as versatile scaffolds in medicinal chemistry
GFS Fernandes, CB Scarim, SH Kim, J Wu… - RSC Medicinal …, 2023 - pubs.rsc.org
Oxazolidinone is a five-member heterocyclic ring with several biological applications in
medicinal chemistry. Among the three possible isomers, 2-oxazolidinone is the most …
medicinal chemistry. Among the three possible isomers, 2-oxazolidinone is the most …
Design, synthesis, and characterization of TNP-2198, a dual-targeted rifamycin-nitroimidazole conjugate with potent activity against microaerophilic and anaerobic …
Z Ma, S He, Y Yuan, Z Zhuang, Y Liu… - Journal of medicinal …, 2022 - ACS Publications
TNP-2198, a stable conjugate of a rifamycin pharmacophore and a nitroimidazole
pharmacophore, has been designed, synthesized, and evaluated as a novel dual-targeted …
pharmacophore, has been designed, synthesized, and evaluated as a novel dual-targeted …
Strategies for the Discovery of Oxazolidinone Antibacterial Agents: Development and Future Perspectives
P Liu, Y Jiang, L Jiao, Y Luo, X Wang… - Journal of Medicinal …, 2023 - ACS Publications
Oxazolidinones represent a significant class of synthetic bacterial protein synthesis
inhibitors that are primarily effective against Gram-positive bacteria. The commercial …
inhibitors that are primarily effective against Gram-positive bacteria. The commercial …
A novel antibiotic combination of linezolid and polymyxin B octapeptide PBOP against clinical Pseudomonas aeruginosa strains
T Huang, M Zeng, H Fu, K Zhao, T Song, Y Guo… - Annals of Clinical …, 2022 - Springer
Abstract Background Antibiotic-resistant Gram-negative bacteria are becoming a major
public health threat such as the important opportunistic pathogen Pseudomonas aeruginosa …
public health threat such as the important opportunistic pathogen Pseudomonas aeruginosa …
A Potent Antibiotic Combination of Linezolid and Polymycin B Nonapeptide Against Klebsiella pneumoniae Infection In Vitro and In Vivo
T Huang, Z Lv, J Lin, K Zhao, L Zhai, X Wang… - Frontiers in …, 2022 - frontiersin.org
The emergence of antibiotic resistant Gram-negative bacteria such as Klebsiella
pneumoniae (KP) is becoming a major public health threat and imposing a financial burden …
pneumoniae (KP) is becoming a major public health threat and imposing a financial burden …
[HTML][HTML] Oxazolidinones: Are they only good for the discovery of antibiotics? A worm's eye view
S Pathania, K Petrova-Szczasiuk, O Pentikäinen… - Journal of Molecular …, 2023 - Elsevier
Oxazolidinones are one of the well-known classes of O-heterocycles which has yielded
various potent antibiotics. Several oxazolidinone-based antibiotics are either FDA-approved …
various potent antibiotics. Several oxazolidinone-based antibiotics are either FDA-approved …
[引用][C] Synthesis and Antibacterial Activity of 3-Arylaminomethyl-1-(2-Oxo-2-Arylethyl)-6, 7, 8, 9-Tetrahydro-5H-[1, 2, 4] triazolo [4, 3-A] Azepin-1-Ium Bromides and Aryl …
N Demchenko, Z Suvorova, Y Fedchenkova… - ScienceRise …, 2021