Fibrosis is the common end point of chronic kidney disease. The persistent production of
inflammatory cytokines and growth factors leads to an ongoing process of extracellular …

The number of descriptions of emerging viruses has grown at an unprecedented rate since
the beginning of the 21 st century. Severe acute respiratory syndrome coronavirus 2 (SARS …

Abstract Monocyte chemoattractant/chemotactic protein-1 (MCP-1), a member of the CC
chemokine family, is one of the key chemokines that regulate migration and tissue infiltration …

Apoptotic cell death is usually a response to the cell microenvironment. Apoptosis requires
the activation of lethal molecules and the inactivation of prosurvival ones. Both are potential …

Background Apoptosis signal-regulating kinase 1 (ASK1) activation in glomerular and
tubular cells resulting from oxidative stress may drive kidney disease progression. Findings …

Activated signaling cascades in the proximal tubular cells of the kidneys play a crucial role in
the development of tubulointerstitial fibrosis. Inhibition of these signaling cascades with …

Renal fibrosis is the principal process underlying the progression of chronic kidney disease
(CKD) to endstage renal disease (ESRD). It is a relatively uniform response involving …

There is no effective therapy for advanced liver fibrosis. Angiotensin type 1 (AT1) receptor
blockers attenuate liver fibrogenesis, yet their efficacy in reversing advanced fibrosis is …

A novel, EGFR-targeted nanomedicine has been developed in the current study.
Glutaraldehyde crosslinked albumin nanoparticles with a size of approximately 100nm were …

Oxidative stress is an underlying component of acute and chronic kidney disease. Apoptosis
signal–regulating kinase 1 (ASK1) is a widely expressed redox-sensitive serine threonine …