Base excision repair (BER) corrects DNA damage from oxidation, deamination and
alkylation. Such base lesions cause little distortion to the DNA helix structure. BER is …

Nucleotide excision repair (NER) is the main pathway used by mammals to remove bulky
DNA lesions such as those formed by UV light, environmental mutagens, and some cancer …

Summary MRE11 within the MRE11-RAD50-NBS1 (MRN) complex acts in DNA double-
strand break repair (DSBR), detection, and signaling; yet, how its endo-and exonuclease …

Oxidatively induced DNA damage is caused in living organisms by endogenous and
exogenous reactive species. DNA lesions resulting from this type of damage are mutagenic …

Fe–S clusters are partners in the origin of life that predate cells, acetyl-CoA metabolism,
DNA, and the RNA world. The double helix solved the mystery of DNA replication by base …

First discovered as a structure-specific endonuclease that evolved to cut at the base of
single-stranded flaps, flap endonuclease (FEN1) is now recognized as a central component …

Stalled replication forks are a critical problem for the cell because they can lead to complex
genome rearrangements that underlie cell death and disease. Processes such as DNA …

Abstract Structure-specific endonucleases (SSEs) have key roles in DNA replication,
recombination and repair, and emerging roles in transcription. These enzymes have …

The SIBYLS beamline (12.3. 1) of the Advanced Light Source at Lawrence Berkeley
National Laboratory, supported by the US Department of Energy and the National Institutes …

Disruptions in DNA repair pathways predispose cells to accumulating DNA damage. A
growing body of evidence indicates that tumors accumulate progressively more mutations in …