Antimicrobial resistance (AMR) poses a serious threat to human, animal and environmental
health worldwide. Colistin has regained importance as a last-resort treatment against multi …

Colistin is regarded as a last-line drug against serious infections caused by multidrug-
resistant Gram-negative bacterial pathogens. Therefore, the emergence of mobile colistin …

Mobile genetic elements (MGEs) are one of the main vectors for the spread of antimicrobial
resistance (AMR) across bacteria, due to their ability to move horizontally between bacterial …

Mobile colistin resistance (mcr) genes (mcr-1 to mcr-10) are plasmid-encoded genes that
threaten the clinical utility of colistin (COL), one of the highest-priority critically important …

The global dissemination of the mobilized colistin resistance gene, mcr-1, threatens human
health. Recent studies by our group and others have shown that the withdrawal of colistin as …

The spread of antibiotic resistance genes (ARGs) has become a major public health
problem. The recent global spread of colistin-resistance gene mcr-1 via conjugative …

The emergence and spread of antibiotic resistance genes (ARGs) have imposed a serious
threat on global public health. Horizontal gene transfer (HGT) via plasmids is mainly …

The emerging and global spread of a novel plasmid-mediated colistin resistance gene, mcr-
1, threatens human health. Expression of the MCR-1 protein affects bacterial fitness and this …

Conjugative plasmids play a vital role in bacterial evolution and promote the spread of
antibiotic resistance. They usually cause fitness costs that diminish the growth rates of the …

Mobile genetic elements (MGEs) are crucial for horizontal gene transfer (HGT) in bacteria
and facilitate their rapid evolution and adaptation. MGEs include plasmids, integrative and …