Neutrophils are critical to innate immunity, including host defense against bacterial and
fungal infections. They achieve their host defense role by phagocytosing pathogens …

Numerous post-translational modifications (PTMs) govern the collective metabolism of a cell
through altering the structure and functions of proteins. The action of the most prevalent …

Stimulator of interferon genes (STING) is an essential adaptor protein required for the
inflammatory response to cytosolic DNA. dsDNA activates cGAS to generate cGAMP, which …

Conspectus Proteins are well-known to undergo a variety of post-translational modifications
(PTMs). One such PTM is citrullination, an arginine modification that is catalyzed by a group …

The systemic spread of malignancies and the risk of cancer-associated thrombosis are
major clinical challenges in cancer therapy worldwide. As an important post-translational …

Abstract Peptide arginine deiminase 2 (PAD2) catalyzes the conversion of arginine residues
on target proteins to citrulline residues in the presence of calcium ions. This particular …

The generation of post-translational modifications (PTMs) in human proteins is a
physiological process leading to structural and immunologic variety in proteins, with …

Citrullination is a post-translational modification (PTM) that converts peptidyl-arginine into
peptidyl-citrulline; citrullination is catalyzed by the protein arginine deiminases (PADs). This …

In rheumatoid arthritis, an autoimmune inflammatory arthritis, citrullinated proteins are
targeted by autoantibodies and thus thought to drive disease. Neutrophil extracellular traps …

Outer membrane and membrane vesicles (OMV/MV) are released from bacteria and
participate in cell communication, biofilm formation and host-pathogen interactions …